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CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification
Atrial fibrillation (AF) is an increasingly prevalent arrhythmia with significant health and socioeconomic impact. The underlying mechanism of AF is still not well understood. In this study, we sought to identify hub genes involved in AF, and explored …
Publication
β-elemene blocks lipid-induced inflammatory pathways via PPARβ activation in heart failure
This study aims to investigate the effects of β-elemene on a mouse model of heart failure (HF) and to elucidate the underlying mechanisms in vitro approaches. In this study, left anterior descending (LAD)-induced HF mouse model and oxygen-glucose …
Publication
Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis
Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed …
Publication
Continuous long-term recording and triggering of brain neurovascular activity and behaviour in freely moving rodents
A minimally invasive, microchip-based approach enables continuous long-term recording of brain neurovascular activity, heart rate, and head movement in freely behaving rodents. This approach can also be used for transcranial optical triggering of cortical …
Publication
Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats
Spinal cord injury (SCI) impairs the cardiovascular responses to postural challenge, leading to the development of orthostatic hypotension (OH). Here, we apply lower body negative pressure (LBNP) to rodents with high-level SCI to demonstrate the …
Publication
Sympathoinhibition and vasodilation contribute to the acute hypotensive response of the superoxide dismutase mimic, MnTnBuOE-2-PyP5+, in hypertensive animals
The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particu- larly superoxide (O 2 •− ), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O 2 •− has been …
Publication
Sex differences in cardiopulmonary effects of acute bromine exposure
Accidental occupational bromine (Br> 2> ) exposures are common, leading to significant morbidity and mortality; however, the specific effects of Br> 2> inhalation in female victims are unclear. Our studies demonstrated that acute high-concentration Br> 2> …
Publication
Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway
Objective: To evaluate the protective effects of Astragaloside IV (AST) in a rat model of myocardial injury induced by cecal ligation and puncture (CLP). Methods: The model of sepsis-induced cardiac dysfunction was induced by CLP. Using a random number …
Publication
Sacubitril/valsartan decreases mortality in the rat model of the isoprenaline-induced takotsubo-like syndrome
Aims: Takotsubo syndrome (TTS) is an acute potentially reversible cardiac syndrome characterized by variable regional myocardial akinesia that cannot be attributed to a culprit coronary artery occlusion. TTS is an important differential diagnosis of acute …
Publication
Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins
The mevalonate pathway is essential for cholesterol biosynthesis. Previous studies have suggested that the key enzyme in this pathway, farnesyl diphosphate synthase (FDPS), regulates the cardiovascular system. We used human samples and mice that were …