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Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats
Purpose: The purpose of the study is to identify potential mechanisms involved in the cardiac protective effects of sitagliptin in Zucker diabetic fatty (ZDF) rats. Methods and Results: Male non-diabetic lean Zucker rats (Lean) and ZDF rats treated with …
Publication
Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFR T790M -Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery
Precision medicine has made a significant breakthrough in the past decade. The most representative success is the molecular targeting therapy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in nonsmall- cell lung cancer (NSCLC) …
Publication
Non-linear Wave Propagation and Safety Standards for Diagnostic Ultrasound Devices
Safety standards for clinical diagnostic ultrasonic devices were developed for use in relatively low- frequency systems (1?10 MHz), under the assumption that non-linear effects would be negligible. This article reviews ways in which neglecting non-linear …
Publication
HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation
Doxorubicin (Dox) is an efficacious antineoplastic drug but is limited used for its cardiotoxicity. Histone Deacetylase 6 (HDAC6) has been indicated to participate in cardiomyopathies, however, its role in Dox-induced cardiac injury is largely unknown. In …
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Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models
Preterm birth (PTB), the leading cause of neonatal morbidity and mortality, urgently requires novel therapeutic agents. Spontaneous PTB, resulting from preterm labor, is commonly caused by intrauterine infection/inflammation. Statins are well-established, …
Publication
Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics
Background-—The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. The presence of Sigmar1 in the heart was first reported on the basis of a ligand-binding assay, and all studies to date have …
Publication
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain …
Publication
Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice
CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake shows a …
Publication
RET, a Targetable Driver of Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease, affecting about 40,000 individuals in the United States annually. We aimed to characterize the role of RET as a co-driver of pancreas tumorigenesis. To assess the role of RET as a co-driver …
Publication
Integration of Polymerization and Biomineralization as a Strategy to Facilely Synthesize Nanotheranostic Agents
Integration of biological macromolecules with inorganic materials via biomineralization has demon- strated great potential for development of nanotheranostic agents. To produce multifunctionality, integration of multiple components in the biomineralized …