Cardiac fibrosis in post-myocardial infarction (MI), seen in both infarcted and non-infarcted myocardium, is beneficial to the recovery of heart function. But progressively pathological fibrosis impairs ventricular function and leads to poor prognosis. …

2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside (TSG) is a water-soluble active component extracted from Polygonum multiflorum Thunb. A number of studies demonstrate that TSG exerts cardioprotective effects. Since endoplasmic reticulum (ER) stress …

Abdominal aortic aneurysms (AAAs) represent a potentially life-threatening condition that predominantly affects the infrarenal aorta. Several preclinical murine models that mimic the human condition have been developed and are now widely used to …

EKV (high frame rate) acquisition of the parasternal long axis view of the murine left ventricle imaged with the MX550D on the Vevo 3100. … … Parasternal Long Axis View of the Murine Left …

Time-dependent alterations in the ultrasonography characteristics of lymph nodes during early-stage metastasis have not been compared with those of tumor-draining lymph nodes that do not develop tumor; this is partly due to the absence of an appropriate …

Backgroud: Macrophages are important mediators in inflammatory cardiovascular diseases. Experi- mental autoimmunemyocarditis (EAM) is characterized by pronouncedmacrophages infiltration, cardiac necrosis and cardiac fibrosis. Androgen receptor (AR) is a …

BACKGROUND: Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentially …

In the failing heart, iNOS is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized iNOS exacerbates left ventricular (LV) remodeling. Wild-type (WT) C57BL/6 mice underwent total body irradiation and …

The chemotherapeutic use of doxorubicin (Dox) is hindered due to the development of irreversible cardiotoxicity. Specifically, childhood cancer survivors are at greater risk of Dox-induced cardiovascular complications. Because of the potent …

Apical 4 chamber view of the mouse heart in B-Mode with all four chambers labelled. … … Apical 4 Chamber view …