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Up‐regulation of miR‐195 contributes to cardiac hypertrophy‐induced arrhythmia by targeting calcium and potassium channels
Previous studies have confirmed that miR-195 expression is increased in cardiac hypertrophy, and the bioinformatics website predicted by Targetscan software shows that miR-195 can directly target CACNB1, KCNJ2 and KCND3 to regulate Cavβ1, Kir2.1 and Kv4.3 …
Publication
Nck1, But Not Nck2, Mediates Disturbed Flow‐Induced p21‐Activated Kinase Activation and Endothelial Permeability
BACKGROUND: Alteration in hemodynamic shear stress at atheroprone sites promotes endothelial paracellular pore formation and permeability. The molecular mechanism remains unknown. METHODS AND RESULTS: We show that Nck (noncatalytic region of tyrosine …
Publication
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation
At present, ischemic heart failure (HF) caused by coronary heart disease (CHD) has a high morbidity and mortality, placing a heavy burden on global human health. L-Proline (Pro), a nonessential amino acid and the foundation of proteins in the human body, …
Publication
Quantification of Atherosclerotic Plaque Elasticity Using Ultrasonic Texture Matching
The composition of an atherosclerotic plaque is a major determinant of its vulnerability, i.e. proneness to rupture. This paper proposes an ultrasonic texture matching method, which is shown to reflect the distribution of elastic modulus and is a …
Publication
Sirtuin 3 is essential for hypertension‐induced cardiac fibrosis via mediating pericyte transition
Hypertension is the key factor for the development of cardiac fibrosis and diastolic dysfunction. Our previous study showed that knockout of sirtuin 3 (SIRT3) resulted in diastolic dysfunction in mice. In the present study, we explored the role of SIRT3 …
Publication
3D High-Frequency Ultrasound Imaging of Cartilage-Bone Interface Compared with Micro-CT
Cartilage-bone interface (CBI) is a complex structure which bears important information in pathophysiology of osteoarthritis (OA). While high-frequency ultrasound (US) has been widely used for the investigation of articular cartilage, 3D imaging of CBI …
Publication
Fluence-matching technique using photoacoustic radiofrequency spectra for improving estimates of oxygen saturation
Photoacoustic (PA) signals encode information about the optical absorption and spatial distribution of absorbing chromophores as well as the light distribution in the medium. The wavelength dependence of the latter affects the accuracy in chromophore …
Publication
Identifying modifier genes for hypertrophic cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) severity greatly varies among patients even with the same HCM gene mutations. This variation is largely regulated by modifier gene(s), which, however, remain largely unknown. The current study is aimed to …
Publication
Multimodal Photoacoustic Imaging‐Guided Regression of Corneal Neovascularization: A Non‐Invasive and Safe Strategy
Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)-guided method is purposed …
Publication
Photo-Electro Active Nanocomposite Silk Hydrogel for Spatiotemporal Controlled Release of Chemotherapeutics: An In Vivo Approach Towards Suppressing Solid Tumor Growth
Conventional systemic chemotherapeutic regimens suffer from challenges such as non-specificity, shorter half-life, clearance of drugs and dose-limiting toxicity. Localized delivery of chemotherapeutic drugs through noninvasive spatiotemporally …