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Publication
FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and remodeling of cardiomyocytes …
Publication
CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts
Purpose: Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) components in the myocardium and facilitates the development of heart failure. C1q/tumor necrosis factor-related protein 15 (CTRP15) is a novel member of the CTRP …
Publication
Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice
The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to …
Publication
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) pro- gression. In this study, we perform a comprehensive unbiased …
Publication
Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites
Robust cytotoxic T cell infiltration has proven to be difficult to achieve in solid tumors. We set out to develop a flexible protocol to efficiently transfect tumor and stromal cells to produce immune-activating cytokines, and thus enhance T cell …
Publication
IL-33 Induces Type-2-Cytokine Phenotype but Exacerbates Cardiac Remodeling Post-Myocardial Infarction with Eosinophil Recruitment, Worsened Systolic Dysfunction, and Ventricular Wall Rupture
Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin-33 (IL-33) is a cytokine present in most cardiac cells and is secreted upon necrosis where it acts as a functional ligand for the ST2 receptor. Although IL-33/ST2 axis is …
Publication
Hydrogen Sulfide Promotes Cardiomyocyte Proliferation and Heart Regeneration via ROS Scavenging
Neonatal mouse hearts can regenerate completely in 21 days after cardiac injury, providing an ideal model to exploring heart regenerative therapeutic targets. The oxidative damage by Reactive Oxygen Species (ROS) is one of the critical reasons for the …
Publication
Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR-mediated autophagy flux pathway
Human umbilical cord mesenchymal stem cell‐derived exosomes (hucMSC‐exosomes) have been implicated as a novel therapeutic approach for tissue injury repair and regeneration, but the effects of hucMSC‐exosomes on coxsackievirus B3 (CVB3)‐induced …
Publication
Chemiluminescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics
Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)–mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational …
Publication
Heterogeneity and chimerism of endothelial cells revealed by single-cell transcriptome in orthotopic liver tumors
The liver is a common host organ for cancer, either through lesions that arise in liver epithelial cells [e.g., hepatocellular carcinoma (HCC)] or as a site of metastasis by tumors arising in other organs (e.g., colorectal cancer). However, the changes …