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Photoacoustics (PA)
Our unique photoacoustic Imaging technology is an in vivo hybrid imaging modality. Photoacoustics combines the sensitivity and contrast of optical imaging with the depth and high resolution of our ultrasound technology. When pulsed laser light …
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September 2017: In vivo biodistribution of contrast agents - whole body photoacoustic imaging
Presented by: Jonathan Lavaud from Plateforme OPTIMAL, Institute for Advanced Bioscience In this webinar: Whole body photoacoustic imaging with the Vevo LAZR-X imaging system through extended cross sectional 3D imaging Use of epi- and trans-illumination …
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Pre-Clinical Application Specialist Europe - Amsterdam based (FUJIFILM VisualSonics, Inc.)
FUJILFILM VisualSonics, Inc. VisualSonics is a rapidly growing biomedical company and the world leader in developing high-resolution ultrasound devices for small animal research. VisualSonics offers a pleasant and progressive work environment with a …
Publication
Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction.
AIMS: The incidence and mortality of myocardial infarction (MI) in diabetic patients are higher than in non-diabetic patients; however, the mechanisms by which diabetes results in cardiac dysfunction are poorly understood. The present study tested the …
Publication
FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease.
BACKGROUND: Diabetes is associated with an increased risk of cardiac microvascular disease. The mechanisms by which this damage occurs are unknown. However, research suggests that signaling through the sphingosine-1-phosphates receptor 1 and 3 (S1P1/3) by …
Publication
Analysis of maternal and fetal cardiovascular systems during hyperglycemic pregnancy in the nonobese diabetic mouse.
Preconception or gestationally induced diabetes increases morbidities and elevates long-term cardiovascular disease risks in women and their children. Spontaneously hyperglycemic (d)-NOD/ShiLtJ female mice, a type 1 diabetes model, develop bradycardia and …
Publication
Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling.
Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the alterations in excitation-contraction coupling leading to cardiac dysfunction during diabetes are not …
Publication
Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB.
MG-132, a proteasome inhibitor, can upregulate nuclear factor (NF) erythroid 2-related factor 2 (Nrf2)-mediated antioxidative function and downregulate NF-κB-mediated inflammation. The present study investigated whether through the above two mechanisms …