Search
Publication
Urolithin B improves cardiac function and reduces susceptibility to ventricular arrhythmias in rats after myocardial infarction
Cardiac fibrosis and inflammation play critical roles in ventricular remodelling after myocardial infarction (MI). Urolithin B (UB), a metabolite of ellagitannin-rich foods, has various biological activities, but its effect on ventricular remodelling …
Publication
Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia
Metoprolol (Met) is widely applied in the treatment of myocardial infarction and coronary heart disease in clinic. However, the metabolic network in vivo affected by Met manipulation is still unclear and it's therapeutic molecular mechanisms were remained …
Publication
Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs
Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs). However, hiPSC-derived TEVGs are hampered by low mechanical strength and …
Publication
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to internal …
Publication
Multifunctional Nanoparticles for Multimodal Imaging-Guided Low-Intensity Focused Ultrasound/Immunosynergistic Retinoblastoma Therapy
Retinoblastoma (RB) is prone to delayed diagnosis or treatment and has an increased likelihood of metastasizing. Thus, it is crucial to perform an effective imaging examination and provide optimal treatment of RB to prevent metastasis. Nanoparticles that …
Publication
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart
Current models of B lymphocyte biology posit that B cells continuously recirculate between lymphoid organs without accumulating in peripheral healthy tissues. Nevertheless, B lymphocytes are one of the most prevalent leukocyte populations in the naive …
Publication
A Mitochondria‐Driven Metabolic Sensing Nanosystem for Oxygen Availability and Energy Blockade of Cancer
A mitochondrial targeting and adenosine triphosphate (ATP)‐responsive nanosystem is designed and constructed to interfere with mitochondrial respiration. This triggers metabolic therapy and enhanced photodynamic therapy of malignant tumor via blocking of …
Publication
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction
Background: Traditional preclinical echocardiography (ECHO) modalities, including 1-dimensional motion-mode (M-Mode) and 2-dimensional long axis (2D-US), rely on geometric and temporal assumptions about the heart for volumetric measurements. Surgical …
Publication
Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer
BACKGROUND The lack of facile methods for the specific characterization of malignant thyroid nodules makes the diagnosis of thyroid cancer (TC) challenging. Due to its restricted expression in such nodules, the cell-associated lectin Galectin-3 (Gal3) has …
Publication
Amphiregulin promotes cardiac fibrosis post myocardial infarction by inducing the endothelial-mesenchymal transition via the EGFR pathway in endothelial cells
The endothelial-mesenchymal transition (EndMT) plays a key role in the development of cardiac fibrosis (CF) after acute myocardial infarction (AMI). The results of our previous study showed that amphiregulin (AR) ex- pression was enhanced after MI. …