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Publication
Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure
Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, …
Publication
Early assessment of tumor response to radiation therapy using high-resolution quantitative microvascular ultrasound imaging
Measuring changes in tumor volume using anatomical imaging weeks to months post radiation therapy (RT) is currently the clinical standard for indicating treatment response to RT. For patients whose tumors do not respond successfully to treatment, this …
Publication
Scaffold Composition Determines the Angiogenic Outcome of Cell-Based Vascular Endothelial Growth Factor Expression by Modulating Its Microenvironmental Distribution
Delivery of genetically modified cells overexpressing Vascular Endothelial Growth Factor (VEGF) is a promising approach to induce therapeutic angiogenesis in ischemic tissues. The effect of the protein is strictly modulated by its interaction with the …
Publication
REV-ERB α ameliorates heart failure through transcription repression
A cure for heart failure remains a major unmet clinical need, and current therapies targeting neurohomonal and hemodynamic regulation have limited efficacy. The pathological remodeling of the myocardium has been associated with a stereotypical gene …
Publication
Dietary potassium regulates vascular calcification and arterial stiffness
Vascular calcification is a risk factor that predicts adverse cardiovascular complications of several diseases including atherosclerosis. Reduced dietary potassium intake has been linked to cardiovascular diseases such as hypertension and incidental …
Publication
Tissue-directed Implantation Using Ultrasound Visualization for Development of Biologically Relevant Metastatic Tumor Xenografts
Background: Advances in cancer therapeutics depend on reliable in vivo model systems. To develop biologically relevant xenografts, ultrasound was utilized for tissue-directed implantation of neuroblastoma (NB) cell line and patient-derived tumors in the …
Publication
Energy-Absorbing and Local Plasmonic Nanodiamond/Gold Nanocomposites for Sustained and Enhanced Photoacoustic Imaging
Photoacoustic (PA) imaging is a laser-mediated optical ultrasound-based visualization that allows imaging of optical energy absorbers in deep tissue, offering higher spatial resolution, compared with that of NIR fluorescence. To enhance a gold …
Publication
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive …
Publication
Deregulated Ca 2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin
Obscurins are cytoskeletal proteins with structural and regulatory roles encoded by OBSCN. Mutations in OBSCN are associated with the development of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Specifically, the R4344Q mutation …
Publication
MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents
An innovative approach for cardiac regeneration following injury is to induce endogenous cardiomyocyte (CM)cell cycle re-entry. In the present study, CMs from adult rat hearts were isolated and transfected with cel-miR-67 (control) and rno- miR-210. A …