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MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors
Muscular dystrophies (MDs) are often characterized by impairment of both skeletal and cardiac muscle. Regenerative strategies for both compartments therefore constitute a therapeutic avenue. Mesodermal iPSC-derived progenitors (MiPs) can regenerate both …
Publication
Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing following myocardial infarction
Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after MI. Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages mice show better outcomes post-MI, while aged TG mice show a worse aging …
Publication
Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter
Comparative analyses of transcriptional profiles from humans and mice with cardiovascular pathologies revealed consistently ele- vated expression of MICU2, a regulatory subunit of the mitochon- drial calcium uniporter complex. To determine if MICU2 …
Publication
Therapeutic potential of ghrelin and des-acyl ghrelin against chemotherapy-induced cardiotoxicity
Cancer was considered an incurable disease for many years; however, with the development of anticancer drugs and state-of-the art technologies, it has become curable. Cardiovascular diseases in patients with cancer or induced by cancer chemotherapy have …
Publication
Systemic Evaluation of Vascular Dysfunction by High-Resolution Sonography in an N x -Nitro- L -Arginine Methyl Ester Hydrochloride – Induced Mouse Model of Preeclampsia-Like Symptoms
Objectives—The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial function, by high-resolution sonography in an Nx- nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced mouse model of …
Publication
Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling
Aims NADPH oxidase-4 (Nox4) is an important reactive oxygen species (ROS) source that is upregulated in the hemodynamically overloaded heart. Our previous studies using global Nox4 knockout (Nox4KO) mice demonstrated a protective role of Nox4 during …
Publication
PSMA-targeted theranostic nanocarrier for prostate cancer
Herein, we report the use of a theranostic nanocarrier (Folate-HBPE(CT20p)) to deliver a therapeutic peptide to prostate cancer tumors that express PSMA (folate hydrolase 1). The therapeutic peptide (CT20p) targets and inhibits the chaperonin-containing …
Publication
Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice
Background Sepsis is a leading cause of mortality among patients in intensive care units across the USA. Thioredoxin-1 (Trx-1) is an essential 12 kDa cytosolic protein that, apart from maintaining the cellular redox state, possesses multifunctional …
Publication
Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure
Objective For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most …
Publication
Image Monitoring of the Impaired Phagocytic Activity of Kupffer Cells and Liver Oxygen Saturation in a Mouse Cholangitis Model Using Contrast-Enhanced Ultrasound Imaging and Photoacoustic Imaging
Bile duct ligation (BDL) can cause cholangitis, which is known to induce impaired Kupffer cell (KC) function and increased oxygen consumption in a mouse model. It is important to monitor changes in KC function and tissue oxygen saturation, both of which …