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Glucose-responsive enzymatic biomimetic nanodots for H2O2 self-supplied catalytic photothermal/chemodynamic anticancer therapy
Glucose-responsive enzymatic biomimetic nanodots for H2O2 self-supplied catalytic photothermal/chemodynamic anticancer therapy …
Publication
Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers
Aims Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular toxicity, represented by arterial stiffness and endothelial dysfunction. Both parameters are of interest for cardiovascular risk stratification as they are independent …
Publication
Ultrasound-stimulated microbubbles enhancement of fractionated radiation for tumor treatment
Background: Radiation therapy (XRT) causes numerous biological changes in tumor microenvironment. Radiation vascular response, due to endothelial disruption, can influence treatment outcomes in a dose-dependent manner. Ultrasound-stimulated microbubbles …
Publication
Standardisation and future of preclinical echocardiography
Echocardiography is a non-invasive imaging technique providing real-time information to assess the structure and function of the heart. Due to advancements in technology, ultra-high-frequency transducers have enabled the translation of ultrasound from …
Publication
In Utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat
In utero exposure of rat embryos to dimethadione (DMO), the N-demethylated teratogenic metabolite of the anticonvulsant trimethadione, induces a high incidence of cardiac heart defects including ventricular septal defects (VSDs). The same exposure regimen …
Publication
Direct optogenetic activation of upper airway muscles in an acute model of upper airway hypotonia mimicking sleep onset
Direct optogenetic activation of upper airway muscles in an acute model of upper airway hypotonia mimicking sleep onset …
Publication
Antioxidants stimulate BACH1-dependent tumor angiogenesis
Lung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs), but growing evidence indicates that transcriptional programs beyond HIFs control tumor angiogenesis. …
Publication
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity
Anthracyclines are a class of conventionally and routinely used first-line chemotherapy drugs for cancer treatment. In addition to the direct cytotoxic effects, increasing evidence indicates that the efficacy of the drugs also depends on immunomodulatory …
Publication
Establishing a mouse model of lung metastases using ultrasound-guided right heart ventricle injection
We report a technique to generate a murine model of lung metastases by selectively injecting tumor cells into the right heart ventricle under ultrasound guidance. First, we describe cell preparation and reference animal preparation as previously …
Publication
Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models
Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current …