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Cardiac metabolic deregulation induced by the tyrosine kinase receptor inhibitor sunitinib is rescued by endothelin receptor antagonism
The growing field of cardio-oncology addresses the side effects of cancer treatment on the cardiovascular system. Here, we explored the cardiotoxicity of the antiangiogenic therapy, sunitinib, in the mouse heart from a diagnostic and therapeutic …
Publication
NOTCH3 regulates stem-to–mural cell differentiation in infantile hemangioma
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood. We have found that NOTCH3, a critical regulator of mural cell differentiation and …
Publication
Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
Arenaviruses such as Lassa virus (LASV) cause hemorrhagic fever. Terminal shock is associated with a systemic cytokine storm, but the mechanisms are ill defined. Here we used HLA-A2-expressing mice infected with a monkey-pathogenic strain of lymphocytic …
Publication
Phosphatidylserine targeted single-walled carbon nanotubes for photothermal ablation of bladder cancer
© 2017 IOP Publishing Ltd. Bladder cancer has a 60%-70% recurrence rate most likely due to any residual tumour left behind after a transurethral resection (TUR). Failure to completely resect the cancer can lead to recurrence and progression into higher …
Publication
Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase
The use of doxorubicin (DOXO) as a chemotherapeutic drug has been hampered by cardiotoxicity leading to cardiomyopathy and heart failure. Folic acid (FA) is a modulator of endothelial nitric oxide (NO) synthase (eNOS), which in turn is an important player …
Publication
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression
Mitochondrial dysfunction elicits various stress responses in different model systems, but how these responses relate to each other and contribute to mitochondrial disease has remained unclear. Mitochondrial myopathy (MM) is the most common manifestation …
Publication
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed …
Publication
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β -adrenergic receptor signaling
The oncoprotein Mdm2 is a RING domain–containing E3 ubiquitin ligase that ubiquitinates G protein–coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies showed that …
Publication
Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After …
Publication
PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by targeting STX2
Objective To examine the role of miR-124a in LPS- induced septic cardiac insufficiency where underlying mechanism is unclear. Results Expression of miR-124a was decreased in myocardium of LPS-induced septic cardiac dysfunc- tion model. miR-124a antagomiR …