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Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction
Over the past decade, cell therapies have provided promising strategies for the treatment of ischaemic cardiomyopathy. Particularly, the beneficial effects of stem cells, including bone marrow stem cells (BMSCs), endothelial progenitor cells (EPCs), …
Publication
Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression
Rationale: RNA-binding proteins (RBPs) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in heart failure induced by the chemotherapy drug doxorubicin and their interaction with …
Publication
Customization of bilio-pancreatic limb length to modulate and sustain anti-diabetic effect of gastric bypass surgery
Although Roux-en-Y Gastric Bypass (RYGB) remains the most effective treatment for obesity and type 2 diabetes (T2D), many patients fail to achieve remission, or relapse. Increasing intestinal limb lengths of RYGB may improve outcomes, but the mechanistic …
Publication
Hypertrophied myocardium is vulnerable to ischemia reperfusion injury and refractory to rapamycin-induced protection due to increased oxidative/nitrative stress
Left ventricular hypertrophy (LVH) is causally related to increased morbidity and mortality fol- lowing acutemyocardial infarction (AMI) via still unknownmechanisms. Although rapamycin exerts cardioprotective effects against myocardial …
Publication
Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(L-lysine) Nanocomplexes
Acoustic imaging is affordable and accessible without ionizing radiation. Photoacoustic imaging increases the contrast of traditional ultrasound and can offer good spatial resolution when used at high frequencies with excellent temporal resolution. …
Publication
Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats
Bisoprolol (B) exerts potential cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. Unfolded protein response (UPR) attenuates I/R injury induced apoptosis by reducing oxidative damage and inflammation response. The current …
Publication
Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure
Fluid retention is the main reason for the high hospitalization rate among patients with chronic heart failure (CHF). Given the lack of knowledge about fluid intake regulation and its consequences in patients with CHF, current guidelines do not provide …
Publication
Ultrahigh Frequency Ultrasound Imaging of the Hand : A New Diagnostic Tool for Hand Surgery
Background: Ultrasonography is a cost-effective, noninvasive, and expedient imaging modality with numerous clinical applications. Conventional ultrasound uses transducers with frequencies that range from 5 to 12 MHz. However, ultrahigh frequency …
Publication
MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway
Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for …
Publication
Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression.
Advanced cancer induces fundamental changes in metabolism and promotes cardiac atrophy and heart failure. We discovered systemic insulin deficiency in cachectic cancer patients. Similarly, mice with advanced B16F10 melanoma (B16F10-TM) or colon 26 …