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Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
Background: Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of …
Publication
Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis
Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we …
Publication
Genetic background influences cardiac phenotype in murine chronic kidney disease
Background. Levels of fibroblast growth factor 23 (FGF23) increase early in chronic kidney disease (CKD) and are inde- pendently associated with left ventricular hypertrophy (LVH), heart failure and death. Experimental models of CKD with ele- vated FGF23 …
Publication
Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis
The poor drug delivery to primary and metastatic tumors of breast cancer remains a great challenge for effective antimetastasis therapy. Herein, a tumor microenvironment-activated cabazitaxel micelles decorated with legumain-specific melittin (TCM-legM) …
Publication
PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis
Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear …
Publication
Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice
Pulmonary hypertension (PH) frequently occurs in infants with bronchopulmonary dysplasia (BPD), causing increased mortality and right ventricular (RV) dysfunction that persists into adulthood. A first step in developing better therapeutic options is …
Publication
Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway
Background. The aim of the present study was to observe the effect of RAGE-HMGB1 signal pathway on remote ischemic postconditioning in micewithmyocardial ischemia reperfusioninjury.Methods.Micemodel ofMIRIwas established and randomly divided into three …
Publication
Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes
Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis …
Publication
Biomimetic Copper Sulfide for Chemo-Radiotherapy: Enhanced Uptake and Reduced Efflux of Nanoparticles for Tumor Cells under Ionizing Radiation
Combined chemo-radiotherapy is one of most widely applied treatments for clinical cancer therapy. Herein, it is found in this carefully designed study that ionizing radiation (e.g., X-ray) can significantly increase the cell uptake of many different types …
Publication
Acoustic Properties of Small Animal Soft Tissue in the Frequency Range 12-32 MHz
Quality assurance phantoms are made of tissue-mimicking materials (TMMs) the acoustic properties of which mimic those of soft tissue. However, the acoustic properties of many soft tissue types have not been measured at ultrasonic frequencies > 9 MHz. With …