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Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure
Background Although cardiac and splenic mononuclear phagocytes (MPs), i.e., monocytes, macro- phages and dendritic cells (DCs), are key contributors to cardiac remodeling after myo- cardial infarction, their role in pressure-overload remodeling is …
Publication
Complementary roles of gasotransmitters CO and H 2 S in sleep apnea
Sleep apnea, which is the periodic cessation of breathing during sleep, is a major health problem affecting over 10 million people in the United States and is associated with several sequelae, in- cluding hypertension and stroke. Clinical studies suggest …
Publication
Effect of chromatin structure on quantitative ultrasound parameters
High-frequency ultrasound (~20 MHz) techniques were investigated using in vitro and ex vivo models to determine whether alterations in chromatin structure are responsible for ultrasound backscatter changes in biological samples. Acute myeloid leukemia …
Publication
Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation
The present study focuses on the identification of the gene expression profile of neonatal rat cardiomyocytes (NRVCMs) after dynamic mechanical stretch through microarrays of RNA isolated fromcells stretched for 2, 6 or 24 h. In this analysis,myeloid …
Publication
YiQiFuMai Powder Injection attenuates coronary artery ligation-induced myocardial remodeling and heart failure through modulating MAPKs signaling pathway
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its …
Publication
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling is a multifaceted process that includes activation of fibroblasts and a complex immune response. …
Publication
MIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium
A long non-coding RNA (lncRNA), named myocardial infarction associated transcript (MIAT), has been documented to confer risk of myocardial infarction (MI). The aim of this study is to elucidate the pathophysiological role of MIAT in regulation of cardiac …
Publication
Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis
CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing …
Publication
In vivo photoacoustic lipid imaging in mice using the second near-infrared window
Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical imaging by providing users with label-free optical contrast of tissue. Here, we present a proof-of-concept study for noninvasive in vivo murine lipid imaging …
Publication
Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease
The embryonic process of forming a complex struc- ture such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2+) progenitors are rapidly recruited and assigned, and …