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Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats
Fibroblast growth factor 21 (FGF21), a hormone with multiple metabolic properties, has proven to be pleiotropic biological effects and may play pivotal role in numerous cardiovascular and metabolic diseases in the future. Vascular calcification (VC) is a …
Publication
A long noncoding RNA NR_045363 controls cardiomyocyte proliferation and cardiac repair
Long noncoding RNAs (lncRNAs) play important roles in the regulation of genes involved in cell proliferation. We have previously sought to more globally understand the differences of lncRNA expression between human fetal heart and adult heart to identify …
Publication
Low fat but not soy protein isolate was an effective intervention to reduce non-alcoholic fatty liver disease progression in C57BL/6J mice: Monitored by a novel quantitative ultrasound (QUS) method
Untreated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) lead to irreversible liver damage. We hypothesized that a low-fat diet (LFD) or a high-fat diet (HFD) with soy protein isolate (SPI) would be an effective …
Publication
miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.
OBJECTIVE To investigate the effect of MicroRNA (miRNA)-130a on cardiac function and the expression of tumor necrosis factor-α (TNF-α) in rats with heart failure. MATERIALS AND METHODS The rat heart failure model (n = 30) were established, then divided …
Publication
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
Macrophages promote both injury and repair after myocardial infarction, but discriminating functions within mixed populations remains challenging. Here we used fate mapping, parabiosis and single-cell transcriptomics to demonstrate that at steady state, …
Publication
Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity
Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. Oxidative post-translational …
Publication
Maternal cardiac messenger RNA expression of extracellular matrix proteins in mice during pregnancy and the postpartum period
Pregnancy creates a condition of cardiac volume overload which leads to physiological sive analysis of extracellular matrix protein eccentric hypertrophy of the heart that is reversed in the postpartum period. Pathological (ECM) gene expression combined …
Publication
A rat model of acute kidney injury through systemic hypoperfusion evaluated by micro-US, color and PW-Doppler
Aim To create an animal model of acute renal ischemia induced by systemic hypoperfusion, controllable and reproducible to study, in real time, hemorrhagic shock changes with micro-imaging. Animals and methods Hemorrhagic shock was induced in rats …
Publication
IGF-1 deletion affects renal sympathetic nerve activity , left ventricular dysfunction , and renal function in DOCA-salt hypertensive mice
Methods: The DOCA-salt hypertensive mice models were constructed and the experiment was classified into WT (Wild-type mice) +sham, LID (Liver-specific IGF-1 deficient mice) + sham, WT + DOCA, and LID+ DOCA groups. Enzyme-linked immunosorbent assay (ELISA) …
Publication
Rebuilding post-infarcted cardiac functions by injecting TIIA@PDA NPs-crosslinked ROS sensitive hydrogels
Drug-loaded injectable hydrogels have been proved to possess huge potential for the application in tissue engineering. However, increasing the drug loading capacity and regulating the release system to adapt to the microenvironment after myocardial …