Color Doppler image of aortic valve insufficiency from a parasternal long axis view in a mouse. … … Aortic Valve Insufficiency …

Rationale: Mutations in theLMNAgene, encoding nuclear inner membrane protein Lamin A/C, cause distinct phenotypes, collectively referred to as laminopathies. Heart failure, conduction defects, and arrhythmias are the common causes of death in …

The downregulation of β-adrenergic receptors (β-AR) and decreased cAMP-dependent protein kinase activity in failing hearts results in decreased phosphorylation and inactivation of phosphatase-inhibitor-1 (I-1), a distal amplifier element of β-adrenergic …

Obesity in a mouse model leads to alterations in the maternal metabolome and early placenta transcriptome as well as changes in vascularity later in gestation which may provide a mechanism for decreased fetal growth. … … Diet-induced obesity alters the …

The blood-brain barrier (BBB) prevents the passage of nearly all drugs into the brain, hindering brain cancer treatment. Nanoparticles (NPs) have emerged as promising drug delivery vehicles, due to incorporation of poorly soluble drugs, functionalization …

Nanoparticles can be useful for imaging and drug delivery but generally require intravenous injection to reach their targets. Miragoli et al . delivered nanoparticles carrying peptides to the heart by inhalation rather than injection. The inhaled …

Motility of the rabbit intestine in a model of bowel disease. Cilia within the walls can be seen as well as fecal matter movement. … … Intestinal Cilia in the …

The neocortex is composed of many distinct subtypes of neurons that must form precise subtype-specific connections to enable the cortex to perform complex functions. Callosal projection neurons (CPN) are the broad population of commissural neurons that …

The LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre (KPC) mouse model represents an established and frequently used transgenic model to evaluate novel therapies in pancreatic cancer. Tumor onset is variable in the KPC model between 8 weeks and several months. …

Self-organized dynamics of vortex-like rotating waves or scroll waves underlie complex spatial-temporal pattern formation in many excitable chemical and biological systems1-4. In the heart, filament-like phase singularities5,6associated with …