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Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat.
We hypothesized that neuropeptide Y (NPY) exerts vasoconstrictor properties in sciatic nerve blood supply by a Y1 receptor (Y1R) mechanism. Using Doppler ultrasound (40MHz), we measured blood flow velocity through a sciatic nerve supply artery during …
Publication
Ultrasound-guided needle positioning near the sciatic nerve to elicit compound muscle action potentials from the gastrocnemius muscle of the rat.
The use of ultrasound-guided electrode positioning in near-nerve myography was investigated. This is a minimally invasive technique that allows repeated measurements to increase accuracy and hence decreases animal numbers. Ultrasound imaging of the …
Publication
Assessment of skeletal muscle microcirculation in type 2 diabetes mellitus using dynamic contrast-enhanced ultrasound: A pilot study
Abstract Purpose: To investigate muscular micro-perfusion by employing dynamic contrast-enhanced ultrasound (CEUS) and performing transient arterial occlusion in patients with type 2 diabetes mellitus (DM-2). Methods: Twenty DM-2 patients (mean age, 58 ± …
Publication
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD). Endothelial cell and muscle dysfunction are thought to be important contributors to the etiology of …
Publication
Ultrasound biomicroscopy for biomechanical characterization of healthy and injured triceps surae of rats.
This work describes the use of ultrasound biomicroscopy (UBM) to follow up the degeneration-regeneration process after a laceration injury induced in the lateral gastrocnemius (LG) and soleus (SOL) muscles of rats. UBM (40 MHz) images were acquired and …
Publication
Increased myocardial ischemia-reperfusion injury in renal failure involves cardiac adiponectin signal deficiency
Increased myocardial ischemia- reperfusion injury in renal failure involves cardiac adiponectin signal defi- ciency. Am J Physiol Endocrinol Metab 306: E1055–E1064, 2014. First published March 4, 2014; doi:10.1152/ajpendo.00428.2013.—Plasma lev- els of …
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Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.
Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Recent studies have underscored a critical role for CCL2 (MCP-1)-mediated inflammation in the progression of chronic renal damage in RAS and other chronic renal diseases. In …
Publication
Zebrafish as a Cancer Model
The zebrafish has developed into an important model organism for biomedical research over the last decades. Although the main focus of zebrafish research has traditionally been on developmental biology, keeping and observing zebrafish in the lab led to …
Publication
Do High Frequency Ultrasound Images Support Clinical Skin Assessment ?
Do High Frequency Ultrasound Images Support Clinical Skin Assessment ? …
Publication
Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy
T-cell deficiency related to disease, medical treatment, or aging represents a major clinical challenge and is associated with significant morbidity and mortality in cancer and bone marrow transplantation recipients. This study describes several …