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Pulmonary artery denervation improves hemodynamics and cardiac function in pulmonary hypertension secondary to heart failure
Objectives. This study aimed to determine the benefits and correlated mechanisms of PADN for HF-PH. Background. Pulmonary hypertension (PH) secondary to heart failure (HF) is associated with poor clinical outcomes because there is no proper therapy for …
Publication
Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model
Background: Lesions of the long head of the biceps tendon are often associated with massive rotator cuff tears (MRCTs), and biceps tenotomy is frequently performed for pain relief and functional reservation. However, the efficacy and safety of biceps …
Publication
Effects of Triple-Mutated Hypoxia-Inducible Factor-1α on Angiogenesis and Cardiac Function Improvement in Rats with Myocardial Infarction
BACKGROUND/AIMS The effects of hypoxia-inducible factor-1α (HIF-1α) on angiogenesis and cardiac function improvement in rats with myocardial infarction (MI) is unknown and our current study was to evaluate whether HIF-1α would be beneficial for …
Publication
Alcohol Consumption in Combination with an Atherogenic Diet Increased Indices of Atherosclerosis in Apolipoprotein E/Low‐Density Lipoprotein Receptor Double‐Knockout Mice
BACKGROUND Alcohol abuse and adherence to atherogenic diet (AD; a low-carbohydrate-high-protein diet) have been positively associated with cardiovascular disease. In addition, it has been demonstrated clinically that dietary intake is increased on days …
Publication
Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease
Objective: Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby ACHD …
Publication
Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair
Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) — i.e., transfer of ADP-ribose from NAD to arginine — is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose–arginine bond. …
Publication
Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles
Checkpoint inhibitor (CI) immunotherapy is playing an increasingly prominent role in the treatment of cancer but is effective and durable in only a subset of patients. There are concerted efforts to improve CI therapy through the use of multiple CIs or …
Publication
Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats
Diabetic retinopathy (DR) has become the most frequent cause of impaired visual acuity and blindness in working-age population in developed countries. Here we use diabetic rats to clarify the role of Lycium barbarum polysaccharides (LBP) on DR. We treated …
Publication
pH/NIR-responsive semiconducting polymer nanoparticles for highly effective photoacoustic image guided chemo-photothermal synergistic therapy
ABSTRAC T Multifunctional drug delivery nanoplatform (PDPP3T@PSNiAA NPs) based on NIR absorbing semiconducting polymer nanoparticles for pH/NIR light-controllably regulated drug release has been successfully prepared. In this strategy, …
Publication
Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes
Immune responses contribute to a large extent to heart diseases. However, it is still not clear how the key inflammatory mediator Interferon-γ (IFNγ) plays a role in doxorubicin (DOX)-induced cardiomyopathy. We report here that DOX-induced heart …