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Publication
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed …
Publication
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β -adrenergic receptor signaling
The oncoprotein Mdm2 is a RING domain–containing E3 ubiquitin ligase that ubiquitinates G protein–coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies showed that …
Publication
Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After …
Publication
PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by targeting STX2
Objective To examine the role of miR-124a in LPS- induced septic cardiac insufficiency where underlying mechanism is unclear. Results Expression of miR-124a was decreased in myocardium of LPS-induced septic cardiac dysfunc- tion model. miR-124a antagomiR …
Publication
Luma is not essential for murine cardiac development and function
Aims Luma is a recently discovered, evolutionarily conserved protein expressed in mammalian heart that is associated with the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. The LINC complex structurally integrates the nucleus and the cytoplasm, …
Publication
Wnt11 regulates cardiac chamber development and disease during perinatal maturation
Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. However, the chamber-specific programs of neonatal heart growth are poorly understood. We used integrated systems …
Publication
Monitoring health and reproductive status of olms (Proteus anguinus) by ultrasound
The olm (Proteus anguinus) is a troglomorphic, neotenous amphibian with extraordinary life expectancy and unique adaptations that deserve further investigation. A low reproductive rate and habitat decline render it threatened by extinction. Establishing …
Publication
Biochemical and Biophysical Research Communications Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1
Biochemical and Biophysical Research Communications Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting …
Publication
(Pro)renin receptor expression in myocardial infarction in transgenic mice expressing rat tonin
The (pro)renin receptor [(P)RR] has been implicated as a renin/prorenin receptor, and plays a role in local renin angiotensin system activation. Our goal was to investigate whether a transgenic mouse that expresses rat tonin [TGM'(rTon)] can regulate …
Publication
The effects of fatty acid composition on cardiac hypertrophy and function in mouse models of diet-induced obesity
High-fat diets (HFDs) are used frequently to study the development of cardiac dysfunction in animal models of obesity and diabetes. However, impairment in systolic function, often reported as declining ejection fraction, may not consistently occur in a …