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Protocatechualdehyde reduces myocardial fibrosis by directly targeting conformational dynamics of collagen
Myocardial fibrosis is associated with cardiovascular remodeling, which is characterized by abnormal collagen architecture. However, there are not yet effective strategies targeting this abnormal pathological process. The purpose of our study is to …
Publication
Glucose impairs angiogenesis and promotes ventricular remodelling following myocardial infarction via upregulation of microRNA-17
Hyperglycaemia is known to impair angiogenesis, which may contribute to the poor prognosis of diabetic patients following myocardial infarction (MI). miR-17 has been reported to be involved in the proliferation, migration, and angiogenesis of a variety of …
Publication
Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Patch in Rats with Heart Failure
Background: To treat chronic heart failure (CHF), we developed a robust, easy to handle bio absorbable tissue- engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). This patch …
Publication
Exposure to 17α-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice
17a-ethinyl estradiol (EE2) is a synthetic compound widely used in the generation of contraceptive pills. EE2 is present in the urine of women taking contraceptives and its presence has been confirmed at increasing concentrations contaminating rivers all …
Publication
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy
Aims A 25-base pair deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies the C10 domain (cMyBP-CDC10mut) and is associated with hypertrophic cardiomyopathy (HCM) and heart failure, affecting …
Publication
Early pathological characterization of murine dissecting abdominal aortic aneurysms
We report here on the early pathology of a well-established murine model of dis- secting abdominal aortic aneurysms (AAAs). Continuous infusion of angiotensin II (AngII) into apolipoprotein E-deficient mice induces the formation of aortic dissec- tion and …
Publication
CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity
Mesenchymal stem cells (MSC) are not universal and may be subject to dynamic changes upon local milieus in vivo and after isolation and cultivation in vitro. Here, we demonstrate that MSC derived from murine pericardial adipose tissue (pMSC) constitute …
Publication
Long‐term miR‐29b suppression reduces aneurysm formation in a Marfan mouse model
Aortic root aneurysm formation and subsequent dissection and/or rupture remain the leading cause of death in patients with Marfan syndrome. Our laboratory has reported that miR-29b participates in aortic root/ascending aorta extracellular matrix …
Publication
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms
Objective: Angiotensin (Ang) II type 1 receptor (AT1) activation is essential for the development of exogenous Ang II-induced abdominal aortic aneurysms (AAAs) in hyperlipidemic animals. Experimental data derived from this modeling system, however, …
Publication
Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation
Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly …