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EXPRESS: Echocardiographic Assessment of Right Ventricular Functions in Experimental Pulmonary Hypertension
Echocardiography, a noninvasive and cost-effective method for monitoring cardiac functions, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are …
Publication
Insights into photoacoustic speckle and applications in tumor characterization
In ultrasound imaging, fully-developed speckle arises from the spatiotemporal superposition of pressure waves backscattered by randomly distributed scatterers. Speckle appearance is affected by the imaging system characteristics (lateral and axial …
Publication
Uncoupling Protein 2 Drives Myocardial Dysfunction in Murine Models of Septic Shock
Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Uncoupling protein 2 (UCP2) involves immune response, regulation of oxidative stress, and maintenance of mitochondrial membrane potential as well as …
Publication
Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. …
Publication
Astragalus polysaccharides inhibits cardiomyocyte apoptosis during diabetic cardiomyopathy via the endoplasmic reticulum stress pathway
Ethnopharmacological relevance: Traditional Chinese medicine Astragalus membranaceus (Fisch.) Bunge (AM) has been utilized for the treatment of diabetes mellitus and its complications for centuries. Astragalus poly- saccharides (APS), the main bioactive …
Publication
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4‐ROS‐ADAM17 pathway
Rutaecarpine attenuates hypertensive cardiac hypertrophy in the rats with abdominal artery constriction (AAC); however, its mechanism of action remains largely unknown. Our previous study indicated that NADPH oxidase 4 (Nox4) promotes angiotensin II (Ang …
Publication
Placental malperfusion in response to intrauterine inflammation and its connection to fetal sequelae
Exposure to intrauterine inflammation (IUI) is associated with short- and long-term adverse perinatal outcomes. However, little data exist on utilizing placenta to prognosticate fetal injury in this scenario. Our study aimed to utilize imaging modalities …
Publication
A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post myocardial infarction
Aims: Myelomonocytic cells are critical in injury and healing post myocardial infarction (MI). Mechanisms of regulation, however, are incompletely understood. The aim of the study was to elucidate the role of interferon gamma (IFN-γ) in the orchestrated …
Publication
Development of a quantitative method for evaluating small intestinal motility using ultrasonography in mice
Upper gastrointestinal (GI) motility is affected by various drugs and diseases. However, changes in upper GI motility during these conditions are not well understood, as there are few quantitative in vivo methods that assess small intestinal motility in …
Publication
A Novel Traditional Chinese Medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism
Aims：Prolonged exercise and exercise training can adversely affect cardiac function in some individuals. QiShenYiQi Pills® (QSYQ), a compound Chinese medicine，has been previously shown to improve pressure overload-induced cardiac hypertrophy. We …