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Kruppel-like factor 15 is required for the cardiac adaptive response to fasting
Cardiac metabolism is highly adaptive in response to changes in substrate availability, as occur during fasting. This metabolic flexibility is essential to the maintenance of contractile function and is under the control of a group of select …
Publication
Repeated administrations of cardiac progenitor cells are superior to a single administration of an equivalent cumulative dose
BACKGROUND We have recently found that 3 repeated doses (12×106each) of c-kitPOScardiac progenitor cells (CPCs) were markedly more effective than a single dose of 12×106cells in alleviating postinfarction left ventricular dysfunction and remodeling. …
Publication
Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling
We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP …
Publication
Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this …
Publication
A Novel Mechanism of Mesenchymal Stromal Cell-Mediated Protection against Sepsis: Restricting Inflammasome Activation in Macrophages by Increasing Mitophagy and Decreasing Mitochondrial ROS
Sepsis, a systemic inflammatory response to infection, is the leading cause of death in the intensive care unit (ICU). Previous studies indicated that mesenchymal stromal cells (MSCs) might have therapeutic potential against sepsis. The current study was …
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Liraglutide protects cardiac function in diabetic rats through the PPAR$α$ pathway.
Increasing evidence shows that diabetes causes cardiac dysfunction.We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total of 24 Sprague--Dawley (SD) rats were divided into …
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Intraoperative imaging of lymphatic vessel using ultra high-frequency ultrasound
Intraoperative imaging of lymphatic vessel using ultra high-frequency ultrasound …
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Imaging Corneal Biomechanical Responses to Ocular Pulse Using High-Frequency Ultrasound
Imaging corneal biomechanical changes or abnormalities is important for better clinical diagnosis and treatment of corneal diseases. We propose a novel ultrasound-basedmethod, called ocular pulse elastography (OPE), to image corneal deformation during the …
Publication
2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy
Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2 ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular system, largely independent of the estrogen receptor. 2 ME is a major …
Publication
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation
Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive …