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Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction
We have recently demonstrated that repeated administrations of c-kitPOS cardiac progenitor cells (CPCs) have cumulative beneficial effects in rats with old myocardial infarction (MI), resulting in markedly greater improvement in left ventricular (LV) …
Publication
The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training
Cardiac hypertrophy (CH) is an adaptive pro- cess that exists in two distinct forms and allows the heart to adequately respond to an organism’s needs. The first form of CH is physiological, adaptive and reversible. The second is pathological, irreversible …
Publication
Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice
Background: There is inconclusive evidence about the role of sex as a risk factor for doxorubicin (DOX)-induced cardiotoxicity. Recent experimental studies have shown that adult female rats are protected against DOX-induced cardiotoxicity. However, the …
Publication
Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy
Arrhythmogenic cardiomyopathy (AC) is a hereditary disease leading to sudden cardiac death or heart failure. AC pathology is characterized by cardiomyocyte loss and replacement fibrosis. Our goal was to determine whether cardiomyocytes respond to AC …
Publication
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α
Deletion of Ca2+/calmodulin-dependent protein kinase II delta (CaMKIIδ) has been shown to protect against in vivo ischemia/reperfusion (I/R) injury. It remains unclearwhich CaMKIIδ isoformsand downstreammechanisms are responsible for the salutary effects …
Publication
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia
RATIONALE: Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase in mitochondria, declines with aging and its ablation is associated with accelerated development of cardiovascular diseases. However, the role of SIRT3 in …
Publication
Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways
Pulmonary arterial hypertension (PAH) is a fatal condition for which there is no cure. Dimethyl Fumarate (DMF) is an FDA approved anti-oxidative and anti-inflammatory agent with a favorable safety record. The goal of this study was to assess the …
Publication
High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β 2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts
Patients with diabetes display reduced exercise capability and impaired cardiac contractile reserve in response to adrenergic stimulation. We have recently uncovered an insulin receptor and adrenergic receptor signal network in the heart. The aim of this …
Publication
SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice
Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood …
Publication
Myocardial Tissue Engineering With Cells Derived from Human Induced-Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold
Rationale: Conventional three-dimensional (3D) printing techniques cannot produce structures of the size at which individual cells interact. Objective: Here, we used multiphoton-excited, 3-dimensional printing (MPE-3DP) to generate a native- like, …