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Publication
Comparison of Cognitive Performance and Cardiac Function Between Three Different Rat Models of Vascular Dementia
Purpose: Establishing an ideal animal model is essential for studying the pathogenesis, prevention and treatment of vascular dementia (VD). The present study was designed to compare the differences of behavior, cerebral blood flow (CBF), cardiac output …
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Publication
Theranostic Nanoplatform with Sequential SDT and ADV Effects in Response to Well-Programmed LIFU Irradiation for Cervical Cancer
Background: Some patients with cervical cancer have the need to preserve fertility; there-fore, a minimally invasive treatment option that can effectively inactivate tumors in these patients is necessary. Methods: In this paper, we designed and prepared …
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Publication
Bayesian Regularized Strain Imaging for Assessment of Murine Cardiac Function in vivo
A cardiac strain imaging framework with adaptive Bayesian regularization (ABR) is proposed for in vivo assessment of murine cardiac function. The framework uses ultrasound (US) radio-frequency data collected with a high frequency (f c = 30MHz) imaging …
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Publication
Assessing mechanical vibration-altered wall shear stress in digital arteries
The aim of this study is to implement and validate a method for assessing acute vibration-altered Wall Shear Stress (WSS) in the proper volar digital artery of the non-exposed left forefinger when subjecting the right hand to mechanical vibration. These …
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Publication
Ultrasound strain mapping of the mouse Achilles tendon during passive dorsiflexion
Immediately prior to inserting into bone, many healthy tendons experience impingement from nearby bony structures. However, super-physiological levels of impingement are implicated in insertional tendinopathies. Unfortunately, the mechanisms underlying …
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Publication
Multifunctional Polymeric Nanoparticles for Chemo/Phototheranostics of Retinoblastoma
Retinoblastoma (Rb) is the most critical and severe intraocular malignancy occurring in children. The clinical management of retinoblastoma is still challenging due to failure in early detection and control despite the advancements in medical strategies. …
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Publication
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation
In the process of physiological cardiac repair, splenic leukocyte-activated lipoxygenases (LOXs) are essential for the biosynthesis of specialized pro-resolving lipid mediators as a segment of an active process of acute inflammation in splenocardiac …
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Publication
Connexin 43 hyper-phosphorylation at serine 282 triggers apoptosis in rat cardiomyocytes via activation of mitochondrial apoptotic pathway
Cx43 is the major connexin in ventricular gap junctions, and plays a pivotal role in control of electrical and metabolic communication among adjacent cardiomyocytes. We previously found that Cx43 dephosphorylation at serine 282 (pS282) caused …
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Publication
Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing
Operative treatment is assumed to provide superior outcomes to nonoperative (conservative) treatment following Achilles tendon rupture, however, this remains controversial. This study explores the effect of surgical repair on Achilles tendon healing. Rat …
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Publication
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
Purpose : Astronauts in space vehicles beyond low-Earth orbit will be exposed to high charge and energy (HZE) ions, and there is concern about potential adverse effects on the cardiovascular system. Thus far, most animal studies that assess cardiac …
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