AIMS: Pathological hypertrophy is the result of gene network regulation, which ultimately leads to adverse cardiac remodelling and heart failure (HF) and is accompanied by the reactivation of a 'foetal gene programme'. The Mesenchyme homeobox 1 (Meox1) …

Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged population. However, the cause for the particularly high incidence of injury in this age group is not well understood. Therefore, the objective of this study was to …

The apolipoprotein E-deficient ( apoE –/– ) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontane- ous model recapitulates aspects of human atherosclerosis, and allows for the …

PW Doppler signal from the testicular artery in a mouse. … … Blood Flow in the Murine Testicular Artery …

The clinically used lipid emulsion Intralipid (ILE) reduces ischemia reperfusion injury in healthy rodent hearts. We tested whether ILE is cardioprotective in postinfarct remodeled hearts. Post-infarct remodeled and sham Sprague-Dawley rat hearts were …

Unmethylated CpG oligodeoxynucleotide (CpG-ODN), a Toll-like receptor 9 (TLR9) ligand, has been shown to protect against myocardial ischemia/reperfusion injury. However, the potential effects of CpG-ODN on myocardial infarction (MI) induced by persistent …

Background -Transforming Growth Factor (TGF)-βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We …

The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-Associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging …

As biochemical and functional studies of membrane protein remain a challenge, there is growing interest in the application of nanotechnology to solve the difficulties of developing membrane protein therapeutics. Exosome, composed of lipid bilayer enclosed …

B-Mode image of a mouse bladder (left) and non-pregnant uterus (right). … … Bladder and Uterus in a Mouse …