Cardiovascular complications are common after TBI and are associated with increased morbidity and mortality. In this study, we investigated the possible role of the immune system in mediating cardiac dysfunction post-TBI in mice. Adult male C57BL/6J mice …

Background-Exosomes are membranous vesicles generated by almost all cells. Recent studies demonstrated that mesenchymal stem cell-derived exosomes possessed many effects, including antiapoptosis, anti-inflammatory effects, stimulation of angiogenesis, …

Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune related adverse events, most likely due to the breadth of the induced T-cell …

Listen to the Light: Visualizing Deep Optical Signals with High Resolution! PA-Mode Single Wavelength allows the detection and fusion of photoacoustic signals with detailed anatomical images. Using a tuneable near infrared laser, the subject is …

Spinal cord injury (SCI) is a devastating condition that results in whole-body dysfunction, notably cardiovascular (CV) disruption and disease. Injury- induced destruction of autonomic pathways in conjunction with a progressive decline in physical fitness …

Tissue-mimicking materials (TMMs) are widely used in quality assurance (QA) phantoms to assess the performance of ultrasound scanners. The International Electrotechnical Commission (IEC) defines the acoustic parameters of up to 10 MHz. To manufacture a …

Introduction: Wound healing after myocardial infarction (MI) is mediated by different cell types, secreted proteins, components of the extracellular matrix (ECM) and, as increasing evidences suggest, extracellular vesicles (EVs). We aim to determine the …

Background: In the heart, slow delayed rectifier channels provide outward currents (IKs) for action potential (AP) repolarization in a region- and context-dependent manner. In diseased hearts, chronic elevation of angiotensin II (Ang II) may remodel IKs …

In efforts to improve solid tumor imaging, and enable image-guided drug delivery (IGDD), multiple types of clinical imaging modalities have been combined with nanoparticle platforms1,2. These have improved ability to understand tumor microenvironment and …

The advantage of multispectral imaging is in being able to distinguish optically differing signals from each other. Take advantage of the tuneability of the laser source in order to rapidly acquire photoacoustic data at multiple wavelengths in 2D and 3D …