Apple polyphenol (AP) was found to possess the potential to prevent cancers. Previously, our study showed AP can trigger bladder transitional carcinoma cells to apoptosis and regulate its cell cycle. This study is aimed to evaluate the anticancer effect …

The detrimental effects of myocardial infarction in humans and rodents have a 24-h rhythm. In some human cohorts however, rhythmicity was absent, while the time of maximum damage differs between cohorts. We hypothesized that the type of damage influences …

PW Doppler of the common carotid artery in a rat. … … Rat Carotid Artery Blood Flow …

Diabetic cardiomyopathy (DCM) is one of the major causes of morbidity and mortality in diabetic patients. Recent studies have demonstrated an increased level of fibroblast growth factor 21 (FGF21) in the plasma of DCM patients, and FGF21 has been proven …

Hemodynamic forces play an essential epigenetic role in heart valve development, but how they do so is not known. Here, we show that the shear-respon- sive transcription factor KLF2 is required in endocar- dial cells to regulate the mesenchymal cell …

Rationale: Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile …

We investigate the feasibility of photoacoustic (PA) imaging to quantify the concentration of surface- localized nanoparticles, using tissue-mimicking phantoms and imaging with a commercial PA instrument at 815 nm and a linear-array transducer at a center …

Zebrafish can efficiently regenerate their heart through cardiomyocyte proliferation. In contrast, mammalian cardiomyocytes stop proliferating shortly after birth, limiting the regenerative capacity of the postnatal mammalian heart. Therefore, if the …

Color Doppler image of the bifurcation of the right femoral artery in a mouse. … … Mouse Femoral Artery Bifurcation …

TheMexican axolotl (Ambystoma mexicanum) is an important model species in regenerative biol- ogy. Traditionally, axolotls are anesthetized using benzocaine or MS-222, both of which act to inhibit voltage gated sodium channels thereby preventing action …