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Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. …
Publication
Inflammation, Autophagy, and Apoptosis After Myocardial Infarction.
BACKGROUND There is evidence for inflammation, autophagy, and apoptosis in the ischemic heart. Autophagy is a physiologic process for tissue survival. Apoptosis, on the other hand, is a mechanism that serves to clear the debris in the setting of tissue …
Publication
Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization
Despite improvements in pre-clinical drug testing models, predictability of clinical outcomes continues to be inadequate and costly due to poor evidence of drug metabolism. Humanized miniature organs integrating decellularized rodent organs with tissue …
Publication
TET1 exerts its tumour suppressor function by regulating autophagy in glioma cells
Patients with hyperthyroidism exhibit increased risk of development and progression of cardiac diseases. The activation of the Renin Angiotensin System (RAS) has been indirectly implicated in these cardiac effects observed in hyperthyroidism. …
Publication
Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy
Background/Aims: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. Methods: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) …
Publication
Monitoring circulating prostate cancer cells by in vivo flow cytometry assesses androgen deprivation therapy on metastasis
It remains controversial whether surgical castration prolongs survival rate and improves therapy prospects in patients suffering from prostate cancer. We used PC3 cell line to establish prostate tumor models. In vivo flow cytometry and ultrasonic imaging …
Publication
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice
Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms underlying vascular aging remain unclear. Mitochondrial DNA (mtDNA) damage is linked to aging, but whether mtDNA damage or mitochondrial dysfunction is present and …
Publication
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
Heart failure is a complex end stage result of various cardiovascular diseases; and has a poor prognosis. The mechanisms for the development and progression of heart failure have always been an important topic in cardiovascular research; and previous …
Publication
AMPKα2 deficiency exacerbates long-term PM2.5exposure-induced lung injury and cardiac dysfunction
Previous studies have demonstrated that long-term exposure to fine particulate matter (PM2.5) increases the risk of respiratory and cardiovascular diseases. As a metabolic sensor, AMP-activated protein kinase (AMPK) is a promising target for …
Publication
Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats
Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects in rats. This work aimed to determine whether subcutaneous alamandine injection would attenuate hypertension and cardiac hypertrophy, and improve the function of …