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Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health
The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-Associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging …
Publication
Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy
As biochemical and functional studies of membrane protein remain a challenge, there is growing interest in the application of nanotechnology to solve the difficulties of developing membrane protein therapeutics. Exosome, composed of lipid bilayer enclosed …
Publication
Early dystrophin loss is coincident with the transition of compensated cardiac hypertrophy to heart failure
Hypertension causes cardiac hypertrophy, one of the most important risk factors for heart failure (HF). Despite the importance of cardiac hypertrophy as a risk factor for the development of HF, not all hypertrophied hearts will ultimately fail. …
Publication
Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling
We found that the anticoagulant plasma protease, activated protein C (APC), stimulates the energy sensor kinase, AMPK, in the stressed heart by activating protease-activated receptor 1 (PAR1) on cardiomyocytes. Wild-type (WT) and AMPK-kinase dead (KD) …
Publication
Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice
Background/Aims: The renal resistive index (RI) is a novel candidate as a renal injury prognostic indicator, but it remains unclear how renal RI levels correspond to renal injury in diabetic nephropathy. Methods: To examine this issue, we compared …
Publication
The intake of red raspberry fruit is inversely related to cardiac risk factors associated with metabolic syndrome
The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or …
Publication
Tumour vascular shutdown and cell death following ultrasound-microbubble enhanced radiation therapy
High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation …
Publication
Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy
A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an …
Publication
Nanoscale covalent organic polymers as a biodegradable nanomedicine for chemotherapy-enhanced photodynamic therapy of cancer
Recently, covalent-organic polymers (COPs), which covalently cross-link different types of organic molecules to form organic network structures, have received significant attention in various fields. However, the design of COPs that allows them to act as …
Publication
A Theranostic Nanoplatform: Triple-Model Imaging Guided Synergistic Cancer Therapy Based on Liposomes Conjugated Mesoporous Silica Nanoparticles
Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd), a T1 magnetic resonance imaging (MRI) contrast agent, was doped into MSNs …