Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible …

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is characterized by cardiac conduction abnormalities and left ventricular systolic dysfunction predisposing to heart failure. Previous cardiac …

Nanosized drug delivery systems have offered promising approaches for cancer theranostics. However, few are effective to simultaneously maximize tumor-specific uptake, imaging, and therapy in a single nanoplatform. Here, we report a simple yet …

Quercetin plays an important role in myocardial ischemia and reperfusion injury (IRI). However, the un- derlying mechanism for the protective effect of quercetin is largely unclear. In this study, we explored the protected effects of quercetin against …

Triptolide is the predominant active component of the Chinese herb Tripterygium wilfordii Hook F (TwHF) that has been widely used to treat several chronic inflammatory diseases due to its immuno- suppressive, anti-inflammatory, and anti-proliferative …

Rationale: Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a- 3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, induce cardiac regeneration …

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is characterized by cardiac conduction abnormalities and left ventricular systolic dysfunction predisposing to heart failure. Previous cardiac …

Aims Impaired Ca2þcycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of adrenergic regulation of …

Heart failure is often the consequence of insufficient cardiac regeneration. Neonatal mice retain a certain capability of myocar- dial regeneration until postnatal day (P)7, although the underlying transcriptional mechanisms remain largely unknown. We …

Background-—Cardiomyocyte-specific transgenic mice overexpressing S100A6, a member of the family of EF-hand calcium-binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, …