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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
, Overexpression of the SK3 channel alters vascular remodeling during pregnancy, leading to fetal demise.
American journal of physiology. Endocrinology and metabolism
, Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.
Cardiovascular research
, Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice.
American journal of physiology. Endocrinology and metabolism
, Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy.
Disease models & mechanisms
, Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.
Hypertension
, Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.
Circulation research
, Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Circulation
, TBX5 drives Scn5a expression to regulate cardiac conduction system function
Journal of Clinical Investigation
, Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction.
Circulation research
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