Developmental
Image mouse and rat embryos with superior resolution
From Detecting Pregnancy to Measuring Fetal and Placental Oxygenation and Blood Flow
Vevo ultra-high frequency imaging platforms provide superior resolution ideally suited for developmental and pregnancy research in small animals.
The size, structural details and function of the placenta and developing embryo can be measured over multiple gestational time-points without having to sacrifice your animal.
With the Vevo imaging systems you can:
- Detect and date pregnancy with confidence
- Measure size, blood flow and oxygen saturation in the placenta
- Visualize and measure umbilical blood flow
- Visualize and study fetal organ development
- Measure developing heart contractility and blood vessel flow
- Perform precise image-guided embryo injections
Ideal for research on:
- Developmental toxicity and drug trials
- Fetal programming
- Pregnancy research and pregnancy complications
Images of Interest
Detect and date pregnancy with confidence
Mouse implantation site at mid-gestation.
Measure size, blood flow and oxygen saturation
Spiral arteries with Color Doppler in a mid-gestational mouse placenta.
Visualize and measure umbilical blood flow
Mouse umbilical artery flow at mid-gestation.
Visualize and study fetal organ development
Mouse embryo and placenta showing oxygenation, using photoacoustic imaging.
Gallery
Mouse Ovary - Vevo 3100 vs. Conventional
Mouse ovary acquired using ultra high frequency ultrasound (Vevo 3100) against an image of the same mouse ovary using a conventional ultrasound system.
Pericardial Effusion - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Lesion in Embryo Spine - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Fluid in Brain - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Embryo Cerebellum - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Oxygen saturation in E14 mouse embryo and placenta
In vivo co-registered high-resolution ultrasound (greyscale) and photoacoustic (red, white and blue) image of an E14 embryo and its associated placenta (on left of each image). The photoacoustic signal represents a parametric map of oxygen saturation with red values representing higher sO2. The image was acquired while the mother was breathing medical air (20% O2). Oxygen saturation can be distinguished within differing placental and embryonic anatomy.
Publications
TOP PAPER
Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound
Journal of Circadian Rhythms
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TOP PAPER
In-ovo echocardiography for application in cardiovascular research
Basic Research in Cardiology
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TOP PAPER
Functional photoacoustic imaging for placental monitoring: A mini review
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.
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TOP PAPER
Embryonic echocardiography for assessment of congenital and functional cardiac defects
STAR Protocols
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TOP PAPER
Method to Locate the Uterine Artery in Mice for Micro-Ultrasound Doppler Blood Velocity Examination
The Guide to Investigation of Mouse Pregnancy
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TOP PAPER
A Protocol for Evaluating Vital Signs and Maternal-Fetal Parameters Using High-Resolution Ultrasound in Pregnant Mice
STAR Protocols
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TOP PAPER
Novel insights into the genetic landscape of congenital heart disease with systems genetics
Progress in Pediatric Cardiology
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TOP PAPER
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses
Scientific Reports
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TOP PAPER
Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice
Theranostics
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