Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 21 - 25 of 222 results found
Ultrasound Molecular Imaging of Renal Cell Carcinoma: VEGFR targeted therapy monitored with VEGFR1 and FSHR targeted microbubbles
Alexandre Ingels, Ingrid Leguerney, Paul-Henry Cournède, Jacques Irani, Sophie Ferlicot, Catherine Sébrié, Baya Benatsou, Laurène Jourdain, Stephanie Pitre-Champagnat, Jean-Jacques Patard, Nathalie Lassau
Scientific Reports
.2020
;Comparison of photoacoustic and fluorescence tomography for the in vivo imaging of ICG-labelled liposomes in the medullary cavity in mice
Jana Humbert, Olga Will, Tuula Peñate-Medina, Oula Peñate-Medina, Olav Jansen, Marcus Both, Claus Christian Glüer
Photoacoustics
.2020
;Targeted theranostics of lung cancer: PD-L1-guided delivery of gold nanoprisms with chlorin e6 for enhanced imaging and photothermal/photodynamic therapy
Bin Liu, Guanglei Qiao, Yu Han, E. Shen, Gabriel Alfranca, Haisong Tan, Lirui Wang, Shaojun Pan, Lijun Ma, Wujun Xiong, Yanlei Liu, Daxiang Cui
Acta Biomaterialia
.2020
;In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation
Shengliang Li, Haoting Chen, Haile Liu, Lu Liu, Yuan Yuan, Cong Mao, Wei Zhang, Xiaodong Zhang, Weisheng Guo, Chun-Sing Lee, Xing-Jie Liang
ACS Nano
.2020
;Opto-acoustic synergistic irradiation for vaporization of natural melanin-cored nanodroplets at safe energy levels and efficient sono-chemo-photothermal cancer therapy
Yaxin Hu, Shan Xue, Ting Long, Peizhao Lyu, Xinyu Zhang, Jingqin Chen, Siping Chen, Chengbo Liu, Xin Chen
Theranostics
.2020
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