Photoacoustic & Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated NaGdF4 Nanoparticles
Here the authors report on the synthesis, characterization, and potential utility of ultra-small NaYF4:Nd3+/NaGdF4 nanocrystals coated with manganese dioxide (usNP-MnO2) for spatiotemporal modulation of hypoxia in head and neck squamous cell carcinomas.
The authors demonstrate the following:
- MRI and photoacoustic imaging (PAI) can be used to visualize the release of Mn2+ in vascular channel phantoms
- Local and systemic delivery of the nanoparticles enabled mapping of intratumoral nanoparticle accumulation within patient-derived xenografts
- The potential of hybrid nanoparticles for the modulation of tumor hypoxia in head and neck cancer
- The potential of combined MRI-PAI for simultaneous mapping nanoparticle delivery and oxygenation changes in tumors