Photoacoustic & Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated NaGdF4 Nanoparticles

Here the authors report on the synthesis, characterization, and potential utility of ultra-small NaYF4:Nd3+/NaGdF4 nanocrystals coated with manganese dioxide (usNP-MnO2) for spatiotemporal modulation of hypoxia in head and neck squamous cell carcinomas.

The authors demonstrate the following:

  •  MRI and photoacoustic imaging (PAI) can be used to visualize the release of Mn2+ in vascular channel phantoms
  • Local and systemic delivery of the nanoparticles enabled mapping of intratumoral nanoparticle accumulation within patient-derived xenografts
  • The potential of hybrid nanoparticles for the modulation of tumor hypoxia in head and neck cancer
  • The potential of combined MRI-PAI for simultaneous mapping nanoparticle delivery and oxygenation changes in tumors

 

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