Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 196 - 200 of 222 results found
Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors
Robert J Paproski, Andrew Heinmiller, Keith Wachowicz, Roger J Zemp
Scientific Reports
.2014
;Comparison of dynamic contrast-enhanced MR, ultrasound and optical imaging modalities to evaluate the antiangiogenic effect of PF-03084014 and sunitinib
Cathy C. Zhang, Zhengming Yan, Anand Giddabasappa, Patrick B. Lappin, Cory L. Painter, Qin Zhang, Gang Li, James Goodman, Brett Simmons, Bernadette Pascual, Joseph Lee, Ted Levkoff, Tim Nichols, Zhiyong Xie
Cancer Medicine
.2014
;Contrast-enhanced magneto-photo-acoustic imaging in vivo using dual-contrast nanoparticles
Min Qu, Mohammad Mehrmohammadi, Ryan Truby, Iulia Graf, Kimberly Homan, Stanislav Emelianov
Photoacoustics
.2014
;Multifunctional Albumin–MnO 2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response
Preethy Prasad, Claudia R Gordijo, Azhar Z Abbasi, Azusa Maeda, Angela Ip, Andrew Michael Rauth, Ralph S DaCosta, Xiao Yu Wu
ACS Nano
.2014
;Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice
Kristen a Baltgalvis, Kathy White, W. Li, Mark D Claypool, Wayne Lang, Raniel Alcantara, B. K. Singh, Annabelle M Friera, John McLaughlin, Derek Hansen, Kelly McCaughey, Henry Nguyen, Ira J Smith, Guillermo Godinez, Simon J Shaw, Dane Goff, Rajinder Singh, Vadim Markovtsov, T.-Q. Sun, Yonchu Jenkins, Gerald Uy, Yingwu Li, Alison Pan, Tarikere Gururaja, David Lau, Gary Park, Yasumichi Hitoshi, Donald G Payan, Todd M Kinsella
AJP: Heart and Circulatory Physiology
.2014
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