Visualize and Quantify Contrast Agents in 2D or 3D for Biomarker Research in Small Animals
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments.
Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can be non-invasively visualized deep within the anatomy of the animal in both 2D and 3D with resolutions down to 30 µm.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranostic contrast agents.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion - Displayed as MIP
Tumor Perfusion with Non-Targeted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.