Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Molecular Imaging to Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 221 - 225 of 262 results found
Vascular Endothelial Growth Factor Receptor Type 2–targeted Contrast-enhanced US of Pancreatic Cancer Neovasculature in a Genetically Engineered Mouse Model: Potential for Earlier Detection
Marybeth A. Pysz, Steven B. Machtaler, E. Scott Seeley, John J. Lee, Teresa A. Brentnall, Jarrett Rosenberg, François Tranquart, Jürgen K. Willmann
Radiology
.2015
;Multi-stimuli responsive Cu 2 S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents
Aby Cheruvathoor Poulose, Srivani Veeranarayanan, M. Sheikh Mohamed, Yutaka Nagaoka, Rebeca Romero Aburto, Trevor Mitcham, Pulickel M. Ajayan, Richard R. Bouchard, Yasushi Sakamoto, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar
Nanoscale
.2015
;Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models
Nidal Muhanna, Cheng S Jin, Elizabeth Huynh, Harley Chan, Yi Qiu, Wenlei Jiang, Liyang Cui, Laura Burgess, Margarete K Akens, Juan Chen, Jonathan C Irish, Gang Zheng
Theranostics
.2015
;Subharmonic, non-linear fundamental and ultraharmonic imaging of microbubble contrast at high frequencies.
Verya Daeichin, Johan G Bosch, Andrew Needles, F Stuart Foster, Antonius van der Steen, Nico de Jong
Ultrasound in medicine & biology
.2015
;Ultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 Expression for Endometrial Receptivity Evaluation
Hongmei Liu, Yihan Chen, Fei Yan, Xiaohua Han, Junru Wu, Xin Liu, Hairong Zheng
Theranostics
.2015
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