Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Molecular Imaging to Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 221 - 225 of 256 results found
Protein-based photothermal theranostics for imaging-guided cancer therapy
Pengfei Rong, Peng Huang, Zhiguo Liu, Jing Lin, Albert Jin, Ying Ma, Gang Niu, Lun Yu, Wenbin Zeng, Wei Wang, Xiaoyuan Chen
Nanoscale
.2015
;Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography
Haobin Chen, Zhen Yuan, Changfeng Wu
BioMed Research International
.2015
;Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging
Quli Fan, Kai Cheng, Xiang Hu, Xiaowei Ma, Ruiping Zhang, Min Yang, Xiaomei Lu, Lei Xing, Wei Huang, Sanjiv Sam Gambhir, Zhen Cheng
Journal of the American Chemical Society
.2014
;Dye-Loaded Ferritin Nanocages for Multimodal Imaging and Photothermal Therapy
Peng Huang, Pengfei Rong, Albert Jin, Xuefeng Yan, Molly Gu Zhang, Jing Lin, Hao Hu, Zhe Wang, Xuyi Yue, Wanwan Li, Gang Niu, Wenbin Zeng, Wei Wang, Kechao Zhou, Xiaoyuan Chen
Advanced Materials
.2014
;Sentinel Lymph Node Biopsy Revisited: Ultrasound-Guided Photoacoustic Detection of Micrometastases Using Molecularly Targeted Plasmonic Nanosensors
Geoffrey P Luke, Jeffrey N Myers, Stanislav Y Emelianov, Konstantin V Sokolov
Cancer Research
.2014
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