Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in elderly people. Increased expression of tumor suppressor protein 53 (p53) has been implicated in vascular senescence. Here, we examined the importance of endothelial p53 for …

Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-catenin signaling in this process. In rats with …

Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis …

Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclero- tic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a …

Increasing occurrences of degenerative diseases, defective tissues, and severe cancers heighten the importance of advanced biomedical treat- ments, which in turn enhance the need for improved biomaterials with versatile theranostic functionalities yet …

BACKGROUND: Cardiac fibroblasts are critical mediators of fibrotic remodeling in the failing heart and transform into myofibroblasts in the presence of pro-fibrotic factors such as TGF-β. Myocardial fibrosis worsens cardiac function accelerating the …

Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of …

Exposure to high altitude worsens symptoms and crises in patients with sickle cell disease (SCD). However, it remains unclear if prolonged exposure to low barometric pressures exacerbates SCD etiologies or impairs quality of life. We tested the hypothesis …

Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal blood and, likewise, to regulatory T cells (Tregs) that are expanded to promote maternal tolerance towards the fetus. Here, we report a role of Tregs in promoting …

Rationale: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular …