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The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy
Recently, linkage analysis of two large unrelated multigenerational families identified a novel dilated cardiomyopathy (DCM)-linked mutation in the gene coding for alpha-tropomyosin (TPM1) resulting in the substitution of an aspartic acid for an …
Publication
CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα 12/13
The arachidonic acid-cytochrome P450 2J2-ep- oxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular sys- tem. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac …
Publication
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth
BACKGROUND Exercise promotes metabolic remodeling in the heart, which is associated with physiological cardiac growth; however, it is not known whether or how physical activity-induced changes in cardiac metabolism cause myocardial remodeling. In this …
Publication
Dysfunction of Myosin light-chain 4 (MYL4) leads to heritable atrial cardiomyopathy with electrical, contractile, and structural components: Evidence from genetically-engineered rats
© 2017 The Authors. Background--There is increasing interest in the concept of atrial cardiomyopathy, but the underlying molecular and mechanistic determinants remain poorly defined. We identified a family with heritable atrial cardiomyopathy manifesting …
Publication
MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma
Glioblastoma multiforme (GBM) is the most common and highly malignant primary brain tumor, which is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. To develop novel therapeutic approaches for treatment of GBM, we …
Publication
Lung cancer – associated pulmonary hypertension : Role of microenvironmental inflammation based on tumor cell – immune cell cross-talk
Dyspnea is a frequent, devastating, and poorly understood symptom of advanced lung cancer. In our cohort, among 519 patients who underwent a computed tomography scan for the diagnosis of lung cancer, 250 had amean pulmo- nary artery diameter of > 28mm, …
Publication
Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”
Recent advances in the field of innate immunity have revealed a complex role of innate immune signaling pathways in both tissue homeostasis and disease. Among them, the Toll-like receptor 4 (TLR-4) pathways has been linked to various pathophysiological …
Publication
Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation
Objectives Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent path-ways. We previously generated a catalytically inactive mutant of AC6 …
Publication
QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins
Background The incidence of sudden arrhythmic death is markedly increased in diabetics. Objective The purpose of this study was to develop a mouse model for postmyocardial infarction (post-MI) ventricular tachycardia (VT) in the diabetic heart and …
Publication
Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner
AIM To investigate the role of interleukin-19 (IL-19) in a murine model of female-dominant heart failure (HF). METHODS Expression of one copy of a phosphorylation-deficient cyclic adenosine monophosphate response-element binding protein (dnCREB) causes …