Late-stage ovarian cancer is fatal, and early stage is treatable. Detecting the early stage is a major translational challenge in the research of this cancer. Ultrasound of ovaries and more importantly markers of abnormal growth have made milestones.
In this study, we show that mapping the change in blood oxygen saturation (StO2) with photodynamic therapy (PDT) within the 3D tumor volume could act as a surrogate marker to predict the likelihood of PDT success and could identify regions of local tumor recurrence within this 3D tumor volume.
Bacterial infection is a major cause of morbidity and mortality, especially in the case of antibiotic-resistant strains of S. aureus. A small animal model that uses noninvasive imaging provides a valuable system to study pathogenesis, its treatments, and diagnostic approaches