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Preclinical
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Imaging Zebrafish with High Frequency Ultrasound

Zebrafish are model organisms for biomedical research. There are structural, functional, and genetic similarities with humans that make zebrafish a useful model for not only cardiovascular research but also oncology, developmental biology and aquaculture. Zebrafish are small, develop quickly, and because they are vertebrates, they share many of the same organs and cell types as mammals. 
 

Benefits of Vevo imaging across applications:

Cardiovascular

Oncology

Developmental

  • High-throughput cardiovascular phenotyping
  • Systolic and diastolic function
  • Advanced speckle tracking and strain analysis
  • Tumour detection and sizing superior to visual inspection
  • From the earliest stages



Zebra fish

Above: High frequency ultrasound of the central nervous system of a zebrafish. 


Above: High frequency ultrasound image of zebrafish heart.

Benefits of Vevo high frequency ultrasound for imaging zebrafish:

  • Imaging unaffected by skin pigments
  • Fish imaged in natural environment
  • High frame rates
  • Precise assessment of blood flow and heart rate

Note: No embedding zebrafish in agar (as occasionally done for microscopy). Achieve more precise assessment of blood flow and heart rate.

Investigate cardiovascular changes due to different types of anesthesia, genetic mutations,
diseases (e.g. myocardial infarction), or drug toxicity .


Zebra fish

Above: Whole body scan of an adult zebrafish under tricain anesthesia. Image positioning for zebrafish cardiac phenotyping. Note the zebrafish is lying in a groove to remain in a stable position.

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Interview with Dr. Louis Wang, Victor Chang Cardiac Research Institute, Australia (PI: Diane Fatkin)
Title: A Novel Zebrafish Model Of Human A-Band Truncated Titin Exhibits Altered Ventricular Diastolic Compliance In-Vivo And Reveals Enhanced Susceptibility To The Effects Of Volume Overload