Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound

Melissa M., Dann, Sydney Q., Clark, Natasha A., Trzaskalski, Conner C., Earl, Luke E., Schepers, Serena M., Pulente, Ebonee N., Lennord, Karthik, Annamalai, Joseph M., Gruber, Abigail D., Cox, Ilka, Lorenzen-Schmidt, Richard, Seymour, Kyoung-Han, Kim, Craig J., Goergen, Erin E., Mulvihill

American Journal of Physiology-Heart and Circulatory Physiology |

Our study supports that both 2-D and 4-D echocardiographic analysis techniques are reliable in quantifying infarct size though 4-D ultrasound provides a more holistic image of LV function and structure, especially after myocardial infarction. Furthermore, 4-D strain analysis correctly identifies infarct size and regional LV dysfunction after MI. Therefore, these techniques can improve functional insight into the impact of pharmacological interventions on the pathophysiology of cardiac disease.