Multifunctional and Scalable Nanoparticles for Bimodal Image-Guided Phototherapy in Bladder Cancer Treatment

Menghuan, Tang, Sohaib, Mahri, Ya Ping, Shiau, Tasneem, Mukarrama, Rodolfo, Villa, Qiufang, Zong, Kelsey Jane, Racacho, Yangxiong, Li, Yunyoung, Lee, Yanyu, Huang, Zhaoqing, Cong, Jinhwan, Kim, Yuanpei, Li, Tzu Yin, Lin

Nano-Micro Letters |

Pyropheophorbide a–bisaminoquinoline conjugate lipid nanoparticles (PPBC LNPs), formulated with lipid-based excipients and assembled using microfluidics, exhibit excellent biocompatibility and stability, indicating promise for clinical applications. PPBC LNPs possess remarkable photoacoustic and fluorescence imaging capabilities, enabling high-resolution, deep tissue penetration and high sensitivity imaging for tracking drug biodistribution and phototherapy efficacy.