Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Chongshan, Dai, Qinfeng, Li, Herman I., May, Chao, Li, Guangyu, Zhang, Gaurav, Sharma, A. Dean, Sherry, Craig R., Malloy, Chalermchai, Khemtong, Yuannyu, Zhang, Yingfeng, Deng, Thomas G., Gillette, Jian, Xu, David T., Scadden, Zhao V., Wang

Cell Reports | 2020

Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.

https://doi.org/10.1016/j.celrep.2020.108087