The angiotensin II type 2 receptor attenuates aging-associated arterial stiffness in female mice

Casey G., Turner, Rachel, Kenney, Jennifer, Vorn, Seung Kyum, Kim, Greg, Martin, Lakshmi, Pulakat, Iris Z., Jaffe, Jennifer J., DuPont

American Journal of Physiology-Heart and Circulatory Physiology | 2025

This is the first investigation to show that the angiotensin II type 2 receptor (AT2R) attenuates aging-associated arterial stiffness in middle-aged female mice. The AT2R also attenuates arterial stiffness in young female and male mice, but there are sex-specific molecular mechanisms that contribute to the role of AT2R in vessel stiffening.

https://journals.physiology.org/doi/10.1152/ajpheart.00328.2025