This webinar highlighted the unmatched potential of the FUJIFILM VisualSonics Vevo F2 LAZR-X20 platform for preclinical brain research. The combination of high spatial resolution, real-time functional assessment, and molecular sensitivity enables detailed characterization of disease progression in models including but not limited to brain tumors and stroke. Attendees learned how these tools provide cost-effective, versatile, and clinically relevant insights, surpassing traditional imaging modalities in ease and depth of analysis. The presentations showcased the platforms' effective use in longitudinal studies, targeted therapeutic monitoring, and discovery science, reinforcing VisualSonics' commitment to advancing biomedical imaging innovation.
*All data shown in the symposium were from animals that had skin and skull intact, offering a non-invasive solution for neurology research in mice.
If you're interested in watching a specific talk, please use the links down below.
Speaker 1: Dr. Kristyna Neffeova, Claude Bernard Lyon 1 University, France
Focus: Glioblastoma (skin and skull intact)
Talk title: Multimodal Imaging of Brain Tumors Using High-Frequency Ultrasound and Photoacoustic Imaging
Kristyna presented groundbreaking work using the Vevo F2 LAZR-X platform to study orthotopic glioblastoma brain tumors in mice. She highlighted the capabilities of integrated ultrasound and photoacoustic imaging for noninvasive visualization of tumor growth (3D) and vascular changes (Doppler 3D, oxygenation 3D) over time. Her research emphasized the benefits of high-resolution in vivo brain imaging (skin & skull intact) for capturing tissue oxygenation and vascular remodeling in glioblastoma with an outlook towards molecular imaging for lipid accumulation providing new insights into glioblastoma biology and potential avenues for therapeutic evaluation.
Speaker 2: Professor Emmanuelle Canet Soulas, Claude Bernard Lyon 1 University, France
Focus: Stroke (skin & skull intact)
Talk title: Acute Ischemic Stroke in Brain and treatment evaluation using Multi-modal Imaging with Ultrasound and Photoacoustics
Prof. Canet Soulas focused on multimodal imaging approaches to study ischemic stroke, demonstrating how ultrasound and photoacoustic imaging techniques can be used to assess cerebral blood flow, oxygen metabolism, and tissue viability in rodent models. She praised the Vevo platform as a cost-effective, real-time imaging modality enabling dynamic evaluation of stroke progression and reperfusion, thereby providing an alternative to MRI. Her talk underscored how the Vevo platform can be integrated into a MRI scans, creating findings relevant to move from bench to bedside.
Speaker 3: Dr. Pierre Sicard, Plateforme IPAM/Biocampus (IBiSa / France Life Imaging), France
Talk title: Photoacoustic Imaging of Neurovascular Oxygenation in Cardiovascular Disease Models: From Anesthetized to Awake Mice
Dr. Pierre Sicard presented photoacoustic and ultrasound for assessing the link between heart and brain as well as for traumatic brain injury models. Big focus was on brain oxygenation in 2D (dynamic, real-time) and 3D (whole brain). He highlighted the advantages of PAUS imaging over traditional methods such as MRI, particularly in cost, resolution, and ability to perform longitudinal studies. His talk included the world’s first data of visualizing brain activity in fully conscious mice using the Vevo platform. He showcased sensitive detection of cerebral blood flow changes, oxygen saturation, and vascular remodeling, highlighting the Vevo for imaging the rodent brain.