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Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction.
Journal of the American Heart Association
, Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
, Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.
Hypertension
, Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.
Circulation research
, Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Circulation
, Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice.
American journal of physiology. Endocrinology and metabolism
, Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy.
Disease models & mechanisms
, TBX5 drives Scn5a expression to regulate cardiac conduction system function
Journal of Clinical Investigation
, Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy.
Hypertension
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