This is a recording of a LIVE webinar presented by Alexander da Silva, PhD, Research Scientist IV at the University of Mississippi Medical Center in Jackson, MS
Topics discussed in this webinar:
- Leptin acts on the central nervous system (CNS) to improve cardiac function and slow/halt progression of heart failure induced by myocardial infarction
- Leptin’s CNS-mediated cardiac protection in heart failure requires activation of the brain melanocortin system, and more specifically of melanocortin-4 receptors (MC4R)
- The beneficial cardiac effects of the leptin-MC4R axis is accompanied by increased cardiomyocyte mitochondrial biogenesis and efficiency, substrate oxidation, and cardiomyocyte contractility
- Q&A Session