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Applications-Research Specialities

Ischemia

The Vevo LAZR Photoacoustic Imaging System is a unique research tool optimized for morphological, molecular and functional studies in small animal models of diabetes, stroke and cancer.

Tissue ischemia, as well as blood reperfusion in ischemic organs can be investigated in vivo and in real-time. The physiological and biochemical changes induced in the affected tissue/organ hold important clinical relevance in studies of disease and development of therapeutics.

 

Ischemia induced in mouse hindlimb with a tourniquet showing a steady decline in tissue oxygenation

The possibilities for examining tissue ischemia and perfusion in vivo include:

  • Molecular imaging applications:

    • Nanoparticle-enhanced detection
    • Study multiple contrast agents simultaneously
    • High specificity molecular targeting studies
    • Measure intracellular biomarkers
  • High-resolution imaging of organ and tissue structure

    • Characterization of morphology in 2D and 3D
    • Longitudinal therapeutic monitoring
  • Investigation of vascular structure in 2D and 3D

    • Assess angiogenesis progression
    • Amplify endogenous heme signal
    • Quantify perfusion kinetics
  • Quantification of hypoxia via oxygen saturation

    • Oxygen distribution measurements in tissue or organ of interest
    • Assess hemoglobin content

The Vevo® LAZR Photoacoustic Imaging System combines specific and sensitive optical contrast with the depth and high-resolution offered by ultrasound to truly give the researcher the best of both worlds.

Features:

  • Real-time, non-invasive imaging for longitudinal studies
  • Simple, anatomy-specific oxygen saturation and percent oxygenation measurements
  • Quantification of biological parameters for vascularity including hemoglobin content
  • Detection and quantification of biomarkers (eg. VEGFR2, VCAM)
  • Quantification of perfusion kinetics
  • Specific anatomical information across various tissues, including:
    • Tumor
    • Brain
    • Embryo
    • Hindlimb
    • Testes
    • Abdomen