Learn about Vevo® Technology
The Vevo® platform was the world’s first commercially available high-frequency array based ultrasound imaging system and has since emerged as the gold standard in small animal anatomical and functional in vivo imaging. The Vevo Family of high-frequency Ultrasound products enables the researcher to obtain in vivo anatomical, functional, physiological and molecular data simultaneously, in real-time and with a resolution down to 30 µm. The system is easy to use, non-invasive and fast, providing extremely high throughput when needed. It is designed with the researcher in mind, with system presets and animal handling tools for fast image acquisition and numerous protocols, software and data management tools optimized for today’s scientists.
+ -What is High-Frequency Ultrasound?
Ultrasound imaging is a well-established and validated technology that has been used clinically for many decades to visualize internal organs, soft tissues, tendons, joints and vasculature. VisualSonics® has perfected the use of ultrasound in pre-clinical small animal research by creating high-frequency transducers that offers superior high resolution (down to 30um). The Vevo family of Ultrasound systems was first utilized single element transducer technology enabling frequencies in the 15 to 50 MHz range ( VS40, Vevo 660, and Vevo 770). Today, innovative linear array technology is utilized in the MicroScan series of transducers, on the Vevo 1100 and Vevo 2100 platforms. These array transducers offer frequencies up to 50 MHz, making them ideal for “micro” ultrasound imaging of microtargets at depths of 3 cm and frame rates up to 10,000 frames per second. The Vevo Family has been a critical imaging tool in many fields of research and resulted in over 800 publications in the last ten years.
+ -How does it work?
A handheld transducer with a linear array of piezoelectric elements is used to produce acoustic pulses above 20kHz that deliver sound waves into the animal’s body. Diverse tissues, organs and disease lesions absorb and reflect sound waves differently depending on their density. High-resolution grayscale images are produced when the partially reflected sound waves return to the transducer. The resulting image is viewable instantly and can be captured as a still photograph or movie.
Although B-Mode, which displays a two dimensional cross-section of tissue, is the most common imaging mode with ultrasound, other image types can also be produced:
+ -Why High-Frequency Ultrasound Imaging is your first solution
The growing body of biomedical literature unanimously supports ultrasound imaging on the Vevo as the first choice in preclinical animal research. Our researchers have seen the benefits of ultrasound imaging in studies investigating the mechanisms of disease progression or the quality of interventional procedures. Key benefits of using ultrasound imaging first in your research are as follows:
- Non invasive, non radioactive detection of microtargets
- Co-registration of multiple lines of evidence - at the anatomical, functional, physiological and molecular levels
- Real time detection of anomalies in pre and post investigation in minutes
- Translatable calculations for bench to bedside research
- Compliance with animal welfare on ethical framework of conducting scientific research
You research can benefit with the right Vevo Solution today (scroll down to which product is right for me)
+ - What is Photoacoustic Imaging?
Photoacoustics is a powerful emerging biomedical imaging modality and add-on to the high-frequency Vevo ultrasound technology. It works in combination with ultrasound – in real-time and non-invasively – to go beyond basic imaging, enhancing the level of information researchers can obtain from a B-Mode provides structural information while PD-Mode maps the spatial distribution of blood flow. During photoacoustic imaging, optical contrast from tissues is detected with ultrasound to provide deeper information about the oxygen saturation and hemoglobin concentration Or: hypoxic state of
- the tumor microenvironment to measure hypoxia and angiogenesis in cancer imaging
- vascular networks
- obstetrics, including fetal and maternal physiology
- stroke/ischemia and functional brain imaging studies
All tissue can be imaged in real time and in vivo down to 2 cm in depth with a resolution down to 45 μm.
In addition, the optical imaging capabilities of photoacoutics can be used for contrast applications with dyes as well as molecular imaging applications with nanoparticles. Both ultrasound and optical photoacoustic signals are co-registered, allowing users to track the location of multiple molecular signals detected with dyes or nanoparticles back to the animal’s anatomy.
+ - How does it work?
The Vevo LAZR™ photoacoustic imaging platform uses an innovative ultrasound transducer that has been fused with a laser beam to deliver non-ionizing laser pulses into tissues. The delivered energy is absorbed by tissues and converted into heat, causing a “thermoelastic expansion”. This expansion generates ultrasound waves that are returned to and detected by the transducer to produce images of optical absorption contrast within tissues.
Optical signals, which are co-registered on an ultrasound image for anatomical localization, are generated either from endogenous molecules, such as hemoglobin, or exogenous contrast agents, such as dyes or nanoparticles. The Vevo LAZR is also able to simultaneously display multiple contrast agents representing different targets, all in one imaging plane.
+ - Why photoacoustics on the Vevo LAZR for small animal research?
Next generation molecular imaging research has generated publications on photoacoustic imaging to better understand complex disease mechanisms. Non- invasive photoacoustic imaging on the Vevo LAZR has benefitted research in the following ways.
- Real- time co-registration of molecular events to anatomy
- Rapid detection and volume quantitation of microtargets in minutes
- Multi-target detection and quantitation from one live scan
- Real- time visualization of microtargets within the abdominal and pelvic cavity
- Which product is right for me?
Choose the ideal imaging tool for your animal experimentation studies with the chart below
|Description||Transducer Type||Axial Resolution||Lateral Resolution||Dynamic and Adjustable Focus||Multi-Focus||High Line Density||Synthetic Aperture||Laser Integration||Colour Doppler (2D + 3D)||Power Doppler in Real-Time||Strain Analysis||ECG Gating||Contrast Agent Detection||Nanoparticle Detection|
|High-frequency, high-resolution ultrasound designed and loaded with tools specific for preclinical cardiovascular studies||MS Series high-frequency linear array||30 μm||150 μm||✓||x||x||x||x||✓||✓||x||x||x||x|
|High-frequency, high-resolution ultrasound designed for versatile imaging applications||MS Series high-frequency linear array||30 μm||75 μm||✓||✓||✓||✓||x||✓||✓||✓||✓||✓||x|
|High-frequency, high-resolution ultrasound designed for versatile imaging applications||MX Series high-frequency linear array||30 μm||75 μm||✓||✓||✓||✓||x||✓||✓||✓||✓||✓||x|
|Optical “photoacoustic” imaging add-on to the Vevo® 2100 platform for enhanced and overlaid optical and ultrasound imaging capabilities||MS and LZ Series high-frequency linear array with integrated optical fibers||30 μm||75 μm||✓||✓||✓||✓||✓||✓||✓||✓||✓||✓||✓|
- Foster FS, Hossack J and Anderson SL. Micro-ultrasound for preclinical imaging. Interface Focus 2011 Aug 6;1(4):576-601. doi: 10.1098/rsfs.2011.0037. Epub 2011 Jun 8.
- Needles, A., Heinmiller, A., Sun, J., Theodoropoulos, C., Bates, D., Hirson, D., … Foster, F. (2013). Development and initial application of a fully integrated photoacoustic micro-ultrasound system. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 60(5), 888–97.
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