Photoacoustic imaging for three-dimensional visualization and delineation of basal cell carcinoma in patients

Ulf Dahlstrand, Rafi Sheikh, Aboma Merdasa, Rehan Chakari, Bertil Persson, Magnus Cinthio, Tobias Erlöv, Bodil Gesslein, Malin Malmsjö
Background: Photoacoustic (PA) imaging is an emerging non-invasive biomedical imaging modality that could potentially be used to determine the borders of basal cell carcinomas (BCC) preoperatively in order to reduce the need for repeated surgery. Methods: Two- and three-dimensional PA images were obtained by scanning BCCs using 59 wavelengths in the range 680–970 nm. Spectral unmixing was performed to visualize the tumor tissue distribution. Spectral sig- natures from 38 BCCs and healthy tissue were compared ex vivo. Results and discussion: The PA spectra could be used to differentiate between BCC and healthy tissue ex vivo (p<0.05). Spectral unmixing provided visualization of the overall architecture of the lesion and its border. Conclusion: PA imaging can be used to differentiate between BCC and healthy tissue and can potentially be used to delineate tumors prior to surgical excision. 1.

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