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Preclinical
Clinical

A near-infrared turn-on probe for in vivo chemoselective photoacoustic detection of fluoride ion

Leli Zeng, Yanyan Yuan, Chao Jiang, Jing Mu, Fan Li, Yilin Wan, Han Xu, Junle Qu, Peng Huang, Jing Lin
Dyes and Pigments2019
The detection of fluoride ion (F − ) in living subjects is of value for healthcare and environmental fields. Here, a near-infrared (NIR) turn-on photoacoustic (PA) probe composed of naphthalimide unit, namely LET-1, was developed for chemoselective photoacoustic detection (PAD) of F − . The response and mechanism of the interaction between F − and LET-1 were evaluated through kinetic optical studies, 1 HNMR spectra analysis and docking calculations. The results demonstrated that LET-1 could rapidly recognize F − with good selectivity and high sensitivity. Upon the interaction with F − , this non-photoacoustic LET-1 probe could produce a turn-on PA signal at 680 nm, which was used as an indicator for PAD of F − in living subjects, such as soybean sprout and mouse. The present study provides a new approach for in vivo chemoselective PA detection of anions.
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