Evaluation of utero-placental and fetal hemodynamic parameters throughout gestation in pregnant mice using high-frequency ultrasound
Edgar Hernandez-Andrade, Hyunyoung Ahn, Gabor Szalai, Steven J. Korzeniewski, Bing Wang, Mary King, Tinnakorn Chaiworapongsa, Nandor Gabor Than, Roberto RomeroUltrasound in Medicine and Biology2014
Throughout gestation, changes in maternal and fetal Doppler parameters in pregnant mice, similar to those obtained in human fetuses, were detected using high-frequency ultrasound with a 55-MHz linear probe. In the uterine arteries (UtA), fetal umbilical artery (UA) and fetal ductus venosus (DV) peak systolic velocity increased (UtA, p=0.04; UA, p=0.0004; DV, p=0.02), end-diastolic velocity increased (UtA, p<0.001; UA, p<0.0001; DV, p=0.01) and resistance index decreased (UtA, p=0.0004; UA, p=0.0001; DV, p=0.04) toward the end of pregnancy. In the middle cerebral and carotid arteries, end diastolic velocity increased (p=0.02 and p<0.0001) and resistance index decreased (both vessels, p<0.0001). There was a reduction in the pulsatile pattern in the umbilical vein (p<0.05). The increased velocities and reduced resistance index suggest a progressive increment in blood flow to the fetal mouse toward the end of pregnancy. Fetal and utero-placental vascular parameters in CD-1 mice can be reliably evaluated using high-frequency ultrasound. ?? 2014.