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Comparative study of high-resolution microimaging with 30-MHz scanner for evaluating cardiac function in mice.

Kazue Okajima, Yukio Abe, Kohei Fujimoto, Kana Fujikura, Erin E Girard, Tomohiro Asai, Susan H Kwon, Zhezhen Jin, Yasuhiro Nakamura, Minoru Yoshiyama, Shunichi Homma
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2007
BACKGROUND: The accurate assessment of cardiac function in mice is challenging because of their small heart size and rapid heart rate.\n\nMETHODS: We examined the usefulness of novel high-resolution echocardiography (HRE) with a 30-MHz transducer in evaluating cardiac function in 20 mice compared with conventional echocardiography (CE) with a 13-MHz transducer. The left ventricular (LV) regional wall motion (RWM), LV end-diastolic dimension, fractional shortening, anterior LV wall thickness, E/A, and myocardial performance index were assessed.\n\nRESULTS: RWM analysis was more feasible by HRE than by CE (P < .05). Interobserver agreement in RWM analysis and correlation in LV end-diastolic dimension, fractional shortening, anterior LV wall thickness, E/A, and myocardial performance index were all better with HRE than CE.\n\nCONCLUSIONS: HRE is superior to CE in assessing LV function in mice. HRE is potentially a useful method for accurate assessment of cardiac function in various mice models.
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